Tau protein is involved in various cellular processes, including having a canonical role in
binding and stabilization of microtubules in neurons. Tauopathies are neurodegenerative …

Alzheimer's disease (AD) is the most common cause of dementia worldwide, but the
molecular and cellular mechanisms underlying cognitive impairment remain poorly …

Abstract Alzheimer's disease (AD), the leading cause of dementia, is characterized by the
accumulation of amyloid plaques and neurofibrillary tangles in the brain. This condition …

Recent work has identified dozens of non-coding loci for Alzheimer's disease (AD) risk, but
their mechanisms and AD transcriptional regulatory circuitry are poorly understood. Here …

Late-onset Alzheimer's disease (LOAD) is the most common form of Alzheimer's disease
(AD). However, modeling sporadic LOAD that endogenously captures hallmark neuronal …

Aging is associated with cell senescence and is the major risk factor for AD. We
characterized premature cell senescence in postmortem brains from non-diseased controls …

Altered transcriptional and epigenetic regulation of brain cell types may contribute to
cognitive changes with advanced age. Using single-nucleus multi-omic DNA methylation …

The DNA-based logic circuit, constructed to mimic biochemical reaction networks, is highly
significant in detecting biomarkers at the molecular level. The differences in the expression …

In brain, the striatum is a heterogenous region involved in reward and goal-directed
behaviors. Striatal dysfunction is linked to psychiatric disorders, including opioid use …

The complex pathobiology of late-onset Alzheimer's disease (AD) poses significant
challenges to therapeutic and preventative interventions. Despite these difficulties …