MicroRNAs (miRs, miRNAs) are regulatory small noncoding RNAs, with their roles already
confirmed to be important for post-transcriptional regulation of gene expression affecting cell …

Minimally invasive technologies that can sample and detect cell-free nucleic acid
biomarkers from liquid biopsies have recently emerged as clinically useful for early …

Cystic fibrosis (CF) is the most common monogenic disorder, caused by mutations in the CF
transmembrane conductance regulator (CFTR) gene. Over the last 30 years, tremendous …

Peptide nucleic acid (PNA) is a DNA mimic that shows good stability against nucleases and
proteases, forming strongly recognized complementary strands of DNA and RNA. However …

MicroRNAs that are overexpressed in cystic fibrosis (CF) bronchial epithelial cells (BEC)
negatively regulate CFTR and nullify the beneficial effects of CFTR modulators. We …

The development of systems able to deliver genetic material into a target site is a challenge
for modern medicine. Single-stranded peptide nucleic acids have attracted attention as …

Introduction: Obstructive lung diseases such as cystic fibrosis (CF) and chronic obstructive
pulmonary disease (COPD) are causes of high morbidity and mortality worldwide. CF is a …

Redox‐responsive silica drug delivery systems are synthesized by aeco‐friendly diatomite
source to achieve on‐demand release of peptide nucleic acid (PNA) in tumor reducing …

Lung gene therapy for cystic fibrosis disease has not been successful due to several
challenges such as the absence of an appropriate vector. Therefore, optimal delivery of …

Small molecule drugs known as modulators can treat~ 90% of people with cystic fibrosis
(CF), but do not work for premature termination codon variants such as W1282X (c. 3846G> …