Mutualistic interplay between bacteriophages and bacteria in the human gut

AN Shkoporov, CJ Turkington, C Hill - Nature Reviews Microbiology, 2022 - nature.com
Bacteriophages (phages) are often described as obligate predators of their bacterial hosts,
and phage predation is one of the leading forces controlling the density and distribution of …

Evolutionary dynamics between phages and bacteria as a possible approach for designing effective phage therapies against antibiotic-resistant bacteria

M Hasan, J Ahn - Antibiotics, 2022 - mdpi.com
With the increasing global threat of antibiotic resistance, there is an urgent need to develop
new effective therapies to tackle antibiotic-resistant bacterial infections. Bacteriophage …

Characterization of crAss-like phage isolates highlights Crassvirales genetic heterogeneity and worldwide distribution

MD Ramos-Barbero, C Gómez-Gómez… - Nature …, 2023 - nature.com
Crassvirales (crAss-like phages) are an abundant group of human gut-specific
bacteriophages discovered in silico. The use of crAss-like phages as human fecal indicators …

Viral biogeography of the mammalian gut and parenchymal organs

AN Shkoporov, SR Stockdale, A Lavelle… - Nature …, 2022 - nature.com
The mammalian virome has been linked to health and disease but our understanding of how
it is structured along the longitudinal axis of the mammalian gastrointestinal tract (GIT) and …

Factors affecting variation of the human gut phageome

CA Tobin, C Hill, AN Shkoporov - Annual Review of …, 2023 - annualreviews.org
The gut microbiome is a dense and metabolically active consortium of microorganisms and
viruses located in the lower gastrointestinal tract of the human body. Bacteria and their …

Gut virome-wide association analysis identifies cross-population viral signatures for inflammatory bowel disease

X Tian, S Li, C Wang, Y Zhang, X Feng, Q Yan, R Guo… - Microbiome, 2024 - Springer
Background The gut virome has been implicated in inflammatory bowel disease (IBD), yet a
full understanding of the gut virome in IBD patients, especially across diverse geographic …

Structural atlas of a human gut crassvirus

OW Bayfield, AN Shkoporov, N Yutin, EV Khokhlova… - Nature, 2023 - nature.com
CrAssphage and related viruses of the order Crassvirales (hereafter referred to as
crassviruses) were originally discovered by cross-assembly of metagenomic sequences …

[HTML][HTML] Infant gut DNA bacteriophage strain persistence during the first 3 years of life

YC Lou, LX Chen, AL Borges, J West-Roberts… - Cell Host & Microbe, 2024 - cell.com
Bacteriophages are key components of gut microbiomes, yet the phage colonization process
in the infant gut remains uncertain. Here, we establish a large phage sequence database …

Gut virome: role and distribution in health and gastrointestinal diseases

L Spencer, B Olawuni, P Singh - Frontiers in cellular and infection …, 2022 - frontiersin.org
The study of the intestinal microbiome is an evolving field of research that includes
comprehensive analysis of the vast array of microbes–bacterial, archaeal, fungal, and viral …

Stable coexistence between an archaeal virus and the dominant methanogen of the human gut

DP Baquero, S Medvedeva… - Nature …, 2024 - nature.com
The human gut virome, which is mainly composed of bacteriophages, also includes viruses
infecting archaea, yet their role remains poorly understood due to lack of isolates. Here, we …