S-nitrosylation, the modification by nitric oxide of free sulfhydryl groups in cysteines, has
become an important regulatory mechanism in carcinogenesis and metastasis. S …

The two main blood flow patterns, namely, pulsatile shear (PS) prevalent in straight
segments of arteries and oscillatory shear (OS) observed at branch points, are associated …

Significance: Nitric oxide (NO) plays several distinct roles in endothelial homeostasis.
Except for activating the guanylyl cyclase enzyme-dependent cyclic guanosine …

KRAS mutations are frequently detected in non-small cell lung cancers (NSCLCs). Although
covalent KRAS G12C inhibitors have been developed to treat KRAS G12C-mutant cancers …

Increased endothelial cell (EC) apoptosis is associated with the development of
atherosclerotic plaques that develop predominantly at sites exposed to disturbed flow (DF) …

Background The chemotherapy-resistance of triple-negative breast cancer (TNBC) remains
a major challenge. The Nek2B kinase and β-catenin serve as crucial regulators of mitotic …

Altered macrophage infiltration upon tissue damage results in inadequate healing due to
inappropriate remodeling and stem cell recruitment and differentiation. We investigated in …

The Wnt/β-catenin pathway is one of the most conserved signaling pathways across species
with essential roles in development, cell proliferation, and disease. Wnt signaling occurs at …

Centrosomes are best known as the microtubule organizing centers (MTOCs) of eukaryotic
cells. In addition to their classic role in chromosome segregation, centrosomes play diverse …

Despite significant advances in targeted therapies and immunotherapies, non-small cell
lung cancer (NSCLC) continues to present a global health challenge, with a modest five …