RNA modifications in cancer

Q Tang, L Li, Y Wang, P Wu, X Hou, J Ouyang… - British journal of …, 2023 - nature.com
Currently, more than 170 modifications have been identified on RNA. Among these RNA
modifications, various methylations account for two-thirds of total cases and exist on almost …

Deciphering epitranscriptome: modification of mRNA bases provides a new perspective for post-transcriptional regulation of gene expression

S Kumar, T Mohapatra - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Gene regulation depends on dynamic and reversibly modifiable biological and chemical
information in the epigenome/epitranscriptome. Accumulating evidence suggests that …

The dynamic RNA modification 5‐methylcytosine and its emerging role as an epitranscriptomic mark

L Trixl, A Lusser - Wiley Interdisciplinary Reviews: RNA, 2019 - Wiley Online Library
It is a well‐known fact that RNA is the target of a plethora of modifications which currently
amount to over a hundred. The vast majority of these modifications was observed in the two …

The integral role of RNA in stress granule formation and function

D Campos-Melo, ZCE Hawley… - Frontiers in Cell and …, 2021 - frontiersin.org
Stress granules (SGs) are phase-separated, membraneless, cytoplasmic ribonucleoprotein
(RNP) assemblies whose primary function is to promote cell survival by condensing …

Detection technologies for RNA modifications

Y Zhang, L Lu, X Li - Experimental & Molecular Medicine, 2022 - nature.com
To date, more than 170 chemical modifications have been characterized in RNA, providing a
new layer of gene expression regulation termed the 'epitranscriptome'. RNA modification …

RNA methylations in human cancers

X Han, M Wang, YL Zhao, Y Yang, YG Yang - Seminars in cancer biology, 2021 - Elsevier
RNA methylations, as the prevalent post-transcriptional modifications, are critical in
regulating various biological processes, such as RNA transcription, splicing, structure …

[HTML][HTML] The role of RNA m5C modification in cancer metastasis

Q Zhang, F Liu, W Chen, H Miao, H Liang… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Epigenetic modification plays a crucial regulatory role in the biological processes of
eukaryotic cells. The recent characterization of DNA and RNA methylation is still ongoing …

The epigenetic implication in coronavirus infection and therapy

S Atlante, A Mongelli, V Barbi, F Martelli, A Farsetti… - Clinical …, 2020 - Springer
Epigenetics is a relatively new field of science that studies the genetic and non-genetic
aspects related to heritable phenotypic changes, frequently caused by environmental and …

[HTML][HTML] m1A regulated genes modulate PI3K/AKT/mTOR and ErbB pathways in gastrointestinal cancer

Y Zhao, Q Zhao, PJ Kaboli, J Shen, M Li, X Wu… - Translational …, 2019 - Elsevier
BACKGROUND: Gene expression can be posttranscriptionally regulated by a complex
network of proteins. N1-methyladenosine (m1A) is a newly validated RNA modification …

Roles of RNA modifications in diverse cellular functions

E Wilkinson, YH Cui, YY He - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Chemical modifications of RNA molecules regulate both RNA metabolism and fate. The
deposition and function of these modifications are mediated by the actions of writer, reader …