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Human immunology through the lens of evolutionary genetics
L Quintana-Murci - Cell, 2019 - cell.com
Pathogen-imposed selection pressures have been paramount during human evolution.
Detecting such selection signatures in ancient and modern human genomes can thus help …
Detecting such selection signatures in ancient and modern human genomes can thus help …
Understanding rare and common diseases in the context of human evolution
L Quintana-Murci - Genome biology, 2016 - Springer
The wealth of available genetic information is allowing the reconstruction of human
demographic and adaptive history. Demography and purifying selection affect the purge of …
demographic and adaptive history. Demography and purifying selection affect the purge of …
The Mobile Element Locator Tool (MELT): population-scale mobile element discovery and biology
Mobile element insertions (MEIs) represent∼ 25% of all structural variants in human
genomes. Moreover, when they disrupt genes, MEIs can influence human traits and …
genomes. Moreover, when they disrupt genes, MEIs can influence human traits and …
[HTML][HTML] Genetic adaptation and neandertal admixture shaped the immune system of human populations
H Quach, M Rotival, J Pothlichet, YHE Loh… - Cell, 2016 - cell.com
Humans differ in the outcome that follows exposure to life-threatening pathogens, yet the
extent of population differences in immune responses and their genetic and evolutionary …
extent of population differences in immune responses and their genetic and evolutionary …
Population genomics: advancing understanding of nature
Population genomics is advancing our understanding of evolution, ecology, conservation,
agriculture, forestry, and human health by allowing new and long-standing questions to be …
agriculture, forestry, and human health by allowing new and long-standing questions to be …