[HTML][HTML] Role of IL-6 in the commitment of T cell subsets

T Korn, M Hiltensperger - Cytokine, 2021‏ - Elsevier
IL-6 gained much attention with the discovery that this cytokine is a non-redundant
differentiation factor for Th17 cells and T follicular helper cells. Adaptive immune responses …

IL-17 in the pathogenesis of disease: good intentions gone awry

S Majumder, MJ McGeachy - Annual review of immunology, 2021‏ - annualreviews.org
The IL-17 family is an evolutionarily old cytokine family consisting of six members (IL-17A
through IL-17F). IL-17 family cytokines signal through heterodimeric receptors that include …

[HTML][HTML] Imbalance of regulatory and cytotoxic SARS-CoV-2-reactive CD4+ T cells in COVID-19

BJ Meckiff, C Ramírez-Suástegui, V Fajardo, SJ Chee… - Cell, 2020‏ - cell.com
The contribution of CD4+ T cells to protective or pathogenic immune responses to SARS-
CoV-2 infection remains unknown. Here, we present single-cell transcriptomic analysis of> …

The protective and pathogenic roles of IL-17 in viral infections: friend or foe?

WT Ma, XT Yao, Q Peng, DK Chen - Open biology, 2019‏ - royalsocietypublishing.org
Viral infections cause substantial human morbidity and mortality, and are a significant health
burden worldwide. Following a viral infection, the host may initiate complex antiviral immune …

Activated CD8+ T cells cause long-term neurological impairment after traumatic brain injury in mice

M Daglas, DF Draxler, H Ho, F McCutcheon, A Galle… - Cell reports, 2019‏ - cell.com
Traumatic brain injury (TBI) leaves many survivors with long-term disabilities. A prolonged
immune response in the brain may cause neurodegeneration, resulting in chronic …

Single-cell transcriptomic analysis of SARS-CoV-2 reactive CD4+ T cells

BJ Meckiff, C Ramírez-Suástegui… - Social Science …, 2020‏ - pmc.ncbi.nlm.nih.gov
The contribution of CD4+ T cells to protective or pathogenic immune responses to SARS-
CoV-2 infection remains unknown. Here, we present large-scale single-cell transcriptomic …

[HTML][HTML] Current understanding of West Nile virus clinical manifestations, immune responses, neuroinvasion, and immunotherapeutic implications

F Bai, EA Thompson, PJS Vig, AA Leis - Pathogens, 2019‏ - mdpi.com
West Nile virus (WNV) is the most common mosquito-borne virus in North America. WNV-
associated neuroinvasive disease affects all ages, although elderly and …

Rising star in immunotherapy: development and therapeutic potential of small-molecule inhibitors targeting casitas B cell lymphoma-b (Cbl-b)

L Zhou, J Yang, K Zhang, T Wang… - Journal of Medicinal …, 2024‏ - ACS Publications
Casitas B cell lymphoma-b (Cbl-b) is a vital negative regulator of TCR and BCR signaling
pathways, playing a significant role in setting an appropriate threshold for the activation of T …

Regulation of immune responses by E3 ubiquitin ligase Cbl-b

R Tang, WY Langdon, J Zhang - Cellular immunology, 2019‏ - Elsevier
Casitas B lymphoma-b (Cbl-b), a RING finger E3 ubiquitin ligase, has been identified as a
critical regulator of adaptive immune responses. Cbl-b is essential for establishing the …

The role of regulatory T-cells in the development of endometriosis

J Knez, B Kovačič, A Goropevšek - Human Reproduction, 2024‏ - academic.oup.com
Endometriosis is a benign disease of the female reproductive tract, characterized by the
process of chronic inflammation and alterations in immune response. It is estimated to affect …