Growing evidence suggests chronic low-grade inflammation (LGI) as a possible mechanism
underlying the aging process. Some biological and pharmaceutical compounds may reduce …

Eur J Clin Invest 2010; 40 (8): 742–755 Abstract Background Advanced glycation end‐
products (AGEs) are increased in situations with hyperglycemia and oxidative stress such as …

The molecular signaling mechanisms between glomerular cell types during
initiation/progression of diabetic kidney disease (DKD) remain poorly understood. We …

Objective To synthesize more conclusive evidence on the anti-inflammatory effects of
angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers …

The increased formation of advanced glycation endproducts (AGEs) constitutes a potential
mechanism of hyperglycaemia‐induced micro‐and macrovascular disease in diabetes. In …

OBJECTIVE—The purpose of this study was to determine longitudinal predictors of cognitive
decline in older individuals with diabetes who did not have dementia. RESEARCH DESIGN …

Diabetic kidney disease (DKD) is one of the major causes of morbidity and mortality in
diabetic patients and also the leading single cause of end-stage renal disease in the United …

Inhibition of renin with an active site inhibitor, aliskiren, lowers blood pressure (BP) in
diabetic patients. Here, we studied the time course of the antihypertensive and …

Endothelial dysfunction (ED) is a key event in the onset and progression of vascular
complications associated with diabetes. Regulation of endothelial function and the …

Introduction: Correlations between renal and cardiovascular (CV) pathologies in advanced
kidney or heart disease are well characterised, but less clearly defined in the early stages …