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In vivo confocal microscopy of corneal nerves in health and disease
In vivo confocal microscopy (IVCM) is becoming an indispensable tool for studying corneal
physiology and disease. Enabling the dissection of corneal architecture at a cellular level …
physiology and disease. Enabling the dissection of corneal architecture at a cellular level …
Congenital aniridia beyond black eyes: from phenotype and novel genetic mechanisms to innovative therapeutic approaches
Congenital PAX6-aniridia, initially characterized by the absence of the iris, has progressively
been shown to be associated with other developmental ocular abnormalities and systemic …
been shown to be associated with other developmental ocular abnormalities and systemic …
[HTML][HTML] Congenital aniridia–A comprehensive review of clinical features and therapeutic approaches
Congenital aniridia is a rare genetic eye disorder with total or partial absence of the iris from
birth. In most cases the genetic origin of aniridia is a mutation in the PAX6 gene, leading to …
birth. In most cases the genetic origin of aniridia is a mutation in the PAX6 gene, leading to …
Corneal repair and regeneration: current concepts and future directions
The cornea is a unique tissue and the most powerful focusing element of the eye, known as
a window to the eye. Infectious or non-infectious diseases might cause severe visual …
a window to the eye. Infectious or non-infectious diseases might cause severe visual …
[HTML][HTML] The diagnosis of limbal stem cell deficiency
Limbal stem cells (LSCs) maintain the normal homeostasis and wound healing of corneal
epithelium. Limbal stem cell deficiency (LSCD) is a pathologic condition that results from the …
epithelium. Limbal stem cell deficiency (LSCD) is a pathologic condition that results from the …
Human limbal epithelial stem cell regulation, bioengineering and function
C Bonnet, S González, JAS Roberts… - Progress in retinal and …, 2021 - Elsevier
The corneal epithelium is continuously renewed by limbal stem/progenitor cells (LSCs), a
cell population harbored in a highly regulated niche located at the limbus. Dysfunction …
cell population harbored in a highly regulated niche located at the limbus. Dysfunction …
Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation
Whilst demonstrated extensively in vitro, the control of cell behaviour via modulation of
substrate compliance in live tissues has not been accomplished to date. Here we propose …
substrate compliance in live tissues has not been accomplished to date. Here we propose …
Pathophysiology and genetics of salt-sensitive hypertension
Most hypertensive cases are primary and heavily associated with modifiable risk factors like
salt intake. Evidence suggests that even small reductions in salt consumption reduce blood …
salt intake. Evidence suggests that even small reductions in salt consumption reduce blood …
Pathophysiology of aniridia-associated keratopathy: Developmental aspects and unanswered questions
Aniridia, a rare congenital disease, is often characterized by a progressive, pronounced
limbal insufficiency and ocular surface pathology termed aniridia-associated keratopathy …
limbal insufficiency and ocular surface pathology termed aniridia-associated keratopathy …
Anatomical features and cell-cell interactions in the human limbal epithelial stem cell niche
Epithelial stem cells of the ocular surface are essential for the maintenance of corneal
transparency and therefore for vision. Human corneal/limbal epithelial stem cells (LESCs) …
transparency and therefore for vision. Human corneal/limbal epithelial stem cells (LESCs) …