Inadequate dosing and incomplete treatment regimens, coupled with the ability of the
tuberculosis bacilli to cause latent infections that are tolerant of currently used drugs, have …

Successful treatment of tuberculosis (TB) can be hampered by Mycobacterium tuberculosis
populations that are temporarily able to survive antibiotic pressure in the absence of drug …

The devastating impact of Tuberculosis (TB) has been a menace to mankind for decades.
The World Health Organization (WHO) End TB Strategy aims to reduce TB mortality up to …

The emergence of drug resistance continues to afflict TB control where drug resistant strains
have become a global health concern. Contrary to drug-sensitive TB, the treatment of …

Control of Mycobacterium tuberculosis infection continues to be an issue, particularly in
countries with a high tuberculosis (TB) burden in the tropical and sub-tropical regions. The …

Phenotypic screens for bactericidal compounds are starting to yield promising hits against
tuberculosis. In this regard, whole-genome sequencing of spontaneous resistant mutants …

The efficacy of the standardized four-drug regimen (comprising isoniazid, rifampin,
pyrazinamide, and ethambutol) for the treatment of tuberculosis (TB) is menaced by the …

Highlights•The unique mycobacterial cell wall is a layered structure of carbohydrates and
lipids.•The architecture and biosynthesis of the cell wall have largely been …

Drug repurposing (repositioning) is a dynamically-develo** area in the search for effective
therapy of infectious diseases. Repositioning existing drugs with a well-known …

The emergence of antimicrobial resistance of Gram-negative pathogens has become a
worldwide crisis. The status quo for combating resistance is to employ synergistic …