Uterine glands: developmental biology and functional roles in pregnancy

AM Kelleher, FJ DeMayo, TE Spencer - Endocrine reviews, 2019 - academic.oup.com
All mammalian uteri contain glands in the endometrium that develop only or primarily after
birth. Gland development or adenogenesis in the postnatal uterus is intrinsically regulated …

Early human trophoblast development: from morphology to function

M Gauster, G Moser, S Wernitznig, N Kupper… - Cellular and Molecular …, 2022 - Springer
Human pregnancy depends on the proper development of the embryo prior to implantation
and the implantation of the embryo into the uterine wall. During the pre-implantation phase …

Self-renewing endometrial epithelial organoids of the human uterus

HC Fitzgerald, P Dhakal, SK Behura, DJ Schust… - Proceedings of the …, 2019 - pnas.org
The human endometrium is essential in providing the site for implantation and maintaining
the growth and survival of the conceptus. An unreceptive endometrium and disrupted …

Uterine glands coordinate on-time embryo implantation and impact endometrial decidualization for pregnancy success

AM Kelleher, J Milano-Foster, SK Behura… - Nature …, 2018 - nature.com
Uterine glands are essential for pregnancy establishment. By employing forkhead box A2
(FOXA2)-deficient mouse models coupled with leukemia inhibitory factor (LIF) repletion, we …

[HTML][HTML] MicroRNAs in the regulation of endometrial receptivity for embryo implantation

M Shekibi, S Heng, G Nie - International journal of molecular sciences, 2022 - mdpi.com
Development of endometrial receptivity is crucial for successful embryo implantation and
pregnancy initiation. Understanding the molecular regulation underpinning endometrial …

Uterine luminal epithelium as the transient gateway for embryo implantation

X Ye - Trends in Endocrinology & Metabolism, 2020 - cell.com
The uterine luminal epithelium (LE) is the first maternal contact for an implanting embryo.
Intrauterine fluid resorption, cessation of LE proliferation and apoptosis, and LE structural …

Forkhead box a2 (FOXA2) is essential for uterine function and fertility

AM Kelleher, W Peng, JK Pru, CA Pru… - Proceedings of the …, 2017 - pnas.org
Establishment of pregnancy is a critical event, and failure of embryo implantation and
stromal decidualization in the uterus contribute to significant numbers of pregnancy losses in …

The functional roles of protein glycosylation in human maternal–fetal crosstalk

J Zhong, J Li, GJ Burton, H Koistinen… - Human …, 2024 - academic.oup.com
BACKGROUND The establishment of maternal–fetal crosstalk is vital to a successful
pregnancy. Glycosylation is a post-translational modification in which glycans …

Three-dimensional culture models of human endometrium for studying trophoblast-endometrium interaction during implantation

X Li, SP Kodithuwakku, RWS Chan… - Reproductive Biology …, 2022 - Springer
During implantation, a symphony of interaction between the trophoblast originated from the
trophectoderm of the implanting blastocyst and the endometrium leads to a successful …

Glycocalyx curving the membrane: forces emerging from the cell exterior

JCH Kuo, MJ Paszek - Annual review of cell and developmental …, 2021 - annualreviews.org
Morphological transitions are typically attributed to the actions of proteins and lipids. Largely
overlooked in membrane shape regulation is the glycocalyx, a pericellular membrane coat …