Fitness costs of plasmids: a limit to plasmid transmission

A San Millan, RC MacLean - Microbiology spectrum, 2017 - Am Soc Microbiol
Plasmids mediate the horizontal transmission of genetic information between bacteria,
facilitating their adaptation to multiple environmental conditions. An especially important …

Mobility of plasmids

C Smillie, MP Garcillán-Barcia… - Microbiology and …, 2010 - Am Soc Microbiol
Plasmids are key vectors of horizontal gene transfer and essential genetic engineering tools.
They code for genes involved in many aspects of microbial biology, including detoxication …

CRISPR-Cas-based antimicrobials: design, challenges, and bacterial mechanisms of resistance

A Mayorga-Ramos, J Zúñiga-Miranda… - ACS Infectious …, 2023 - ACS Publications
The emergence of antibiotic-resistant bacterial strains is a source of public health concern
across the globe. As the discovery of new conventional antibiotics has stalled significantly …

Plasmid-mediated horizontal gene transfer is a coevolutionary process

E Harrison, MA Brockhurst - Trends in microbiology, 2012 - cell.com
Conjugative plasmids are key agents of horizontal gene transfer (HGT) that accelerate
bacterial adaptation by vectoring ecologically important traits between strains and species …

Positive selection and compensatory adaptation interact to stabilize non-transmissible plasmids

AS Millan, R Peña-Miller, M Toll-Riera… - Nature …, 2014 - nature.com
Plasmids are important drivers of bacterial evolution, but it is challenging to understand how
plasmids persist over the long term because plasmid carriage is costly. Classical models …

Plasmid transfer in biofilms: a perspective on limitations and opportunities

T Stalder, E Top - NPJ biofilms and microbiomes, 2016 - nature.com
Biofilms dominate microbial life, and their importance for human health and the environment
can no longer be dismissed. Nevertheless many of the processes governing this form of …

Source–sink plasmid transfer dynamics maintain gene mobility in soil bacterial communities

JPJ Hall, AJ Wood, E Harrison… - Proceedings of the …, 2016 - National Acad Sciences
Horizontal gene transfer is a fundamental process in bacterial evolution that can accelerate
adaptation via the sharing of genes between lineages. Conjugative plasmids are the …

Identification of bacterial plasmids based on mobility and plasmid population biology

MP Garcillán-Barcia, A Alvarado… - FEMS microbiology …, 2011 - academic.oup.com
Plasmids contain a backbone of core genes that remains relatively stable for long
evolutionary periods, making sense to speak about plasmid species. The identification and …

Cell-to-cell bacterial interactions promoted by drier conditions on soil surfaces

R Tecon, A Ebrahimi, H Kleyer… - Proceedings of the …, 2018 - National Acad Sciences
Bacterial cell-to-cell interactions are in the core of evolutionary and ecological processes in
soil and other environments. Under most conditions, natural soils are unsaturated where the …

Mathematical models of plasmid population dynamics

JCR Hernández-Beltrán, A San Millán… - Frontiers in …, 2021 - frontiersin.org
With plasmid-mediated antibiotic resistance thriving and threatening to become a serious
public health problem, it is paramount to increase our understanding of the forces that …