Does reduced MHC diversity decrease viability of vertebrate populations?

J Radwan, A Biedrzycka, W Babik - Biological conservation, 2010 - Elsevier
Loss of genetic variation may render populations more vulnerable to pathogens due to
inbreeding depression and depletion of variation in genes responsible for immunity against …

Methods for MHC genoty** in non‐model vertebrates

W Babik - Molecular ecology resources, 2010 - Wiley Online Library
Genes of the major histocompatibility complex (MHC) are considered a paradigm of
adaptive evolution at the molecular level and as such are frequently investigated by …

[PDF][PDF] Population and distribution of Eurasian beaver (Castor fiber)

D Halley, F Rosell, A Saveljev - Baltic Forestry, 2012 - unexpectedwildliferefuge.org
A fter being reduced to about 1,200 anim als in eight isolated populations by the beginning
of the 20th century, Eurasian beavers (Castor fiber) have powerfully recovered in range and …

[LLIBRE][B] Evolutionary conservation genetics

J Höglund - 2009 - books.google.com
Conservation genetics focuses on understanding the role and requirement of genetic
variation for population persistence. However, considerable debate now surrounds the role …

Effects of an MHC‐DRB genotype and allele number on the load of gut parasites in the bank vole Myodes glareolus

A Kloch, W Babik, A Bajer, E Siński… - Molecular …, 2010 - Wiley Online Library
The major histocompatibility complex (MHC) genes code for the proteins responsible for
pathogen recognition. The MHC class II DRB gene is multiplicated in the bank vole, Myodes …

New generation sequencers as a tool for genoty** of highly polymorphic multilocus MHC system

W Babik, P Taberlet, MJ Ejsmond… - Molecular ecology …, 2009 - Wiley Online Library
Accurate genoty** of complex systems, such as the major histocompatibility complex
(MHC) often requires simultaneous analysis of multiple co‐amplifying loci. Here we explore …

Cheetah paradigm revisited: MHC diversity in the world's largest free-ranging population

A Castro-Prieto, B Wachter… - Molecular biology and …, 2011 - academic.oup.com
For more than two decades, the cheetah (Acinonyx jubatus) has been considered a
paradigm of disease vulnerability associated with low genetic diversity, particularly at the …

MHC diversity in bottlenecked populations: a simulation model

MJ Ejsmond, J Radwan - Conservation Genetics, 2011 - Springer
The depletion of variation at MHC loci, which play a crucial role in pathogen recognition, has
been postulated to be one of important extinction risk factors for endangered populations …

Low MHC variation in the endangered Galápagos penguin (Spheniscus mendiculus)

JL Bollmer, FH Vargas, PG Parker - Immunogenetics, 2007 - Springer
The major histocompatibility complex (MHC) is one of the most polymorphic regions of the
genome, likely due to balancing selection acting to maintain alleles over time. Lack of MHC …

Coevolutionary relationship between helminth diversity and MHC class II polymorphism in rodents

J Goüy de Bellocq, N Charbonnel… - Journal of Evolutionary …, 2008 - academic.oup.com
Parasite‐mediated selection on major histocompatibility complex (MHC) genes has mainly
been explored at the intraspecific level, although many molecular studies have revealed …