Anthelmintic resistance is a significant threat to livestock production systems worldwide and
is emerging as an important issue in companion animal parasite management. It is also an …

For more than four decades, the free-living nematode Caenorhabditis elegans has been
extensively used in anthelmintic research. Classic genetic screens and heterologous …

Anthelmintic resistance in human and animal pathogenic helminths has been spreading in
prevalence and severity to a point where multidrug resistance against the three major …

Energy metabolism supports neuronal function. While it is well established that changes in
energy metabolism underpin brain plasticity and function, less is known about how …

Visible phenotypes based on locomotion and posture have played a critical role in
understanding the molecular basis of behavior and development in Caenorhabditis elegans …

Levamisole-sensitive acetylcholine receptors (L-AChRs) are ligand-gated ion channels that
mediate excitatory neurotransmission at the neuromuscular junctions of nematodes. They …

Nicotinic acetylcholine receptors (nAChRs) mediate fast excitatory neurotransmission in
neurons and muscles. To identify nAChR accessory proteins, which may regulate their …

Simple Summary Despite the leaps and bounds in the prevention and treatment of cancer, it
remains the second leading cause of death worldwide. A significant hurdle during cancer …

In the nematode Caenorhabditis elegans, cholinergic motor neurons stimulate muscle
contraction as well as activate GABAergic motor neurons that inhibit contraction of the …

The Caenorhabditis elegans neuromuscular junction (NMJ) contains three
pharmacologically distinct ionotropic receptors: γ-aminobutyric acid receptors, levamisole …