Nucleotide sugars in chemistry and biology

S Mikkola - Molecules, 2020 - mdpi.com
Nucleotide sugars have essential roles in every living creature. They are the building blocks
of the biosynthesis of carbohydrates and their conjugates. They are involved in processes …

Enzymatic and chemoenzymatic synthesis of human milk oligosaccharides and derivatives

J Zheng, H Xu, J Fang, X Zhang - Carbohydrate Polymers, 2022 - Elsevier
Human milk oligosaccharides (HMOs) are complex glycans that are the third largest solid
component in human milk. It has attracted great interest in recent years due to their critical …

[HTML][HTML] Applying probiotics and prebiotics in new delivery formats–is the clinical evidence transferable?

M Cunningham, G Vinderola… - Trends in Food Science …, 2021 - Elsevier
Background There is substantial demand for gut health products incorporating probiotics
and prebiotics. They are being delivered as ingredients in an increasing range of different …

Enzymatic production of prebiotic oligosaccharides

C Vera, A Illanes, C Guerrero - Current Opinion in Food Science, 2021 - Elsevier
Highlights•Non-digestible oligosaccharides (NDOs) are the major class of prebiotic
ingredients.•Synthesis of NDOs allows the upgrade of underutilized carbohydrates.•Enzyme …

Recent progress in synthesis of carbohydrates with sugar nucleotide-dependent glycosyltransferases

L Na, R Li, X Chen - Current opinion in chemical biology, 2021 - Elsevier
Sugar nucleotide-dependent glycosyltransferases (GTs) are key enzymes that catalyze the
formation of glycosidic bonds in nature. They have been increasingly applied in the …

Synthetic glycobiology: parts, systems, and applications

W Kightlinger, KF Warfel, MP DeLisa… - ACS synthetic …, 2020 - ACS Publications
Protein glycosylation, the attachment of sugars to amino acid side chains, can endow
proteins with a wide variety of properties of great interest to the engineering biology …

The vertebrate sialylation machinery: structure-function and molecular evolution of GT-29 sialyltransferases

A Harduin-Lepers - Glycoconjugate Journal, 2023 - Springer
Every eukaryotic cell is covered with a thick layer of complex carbohydrates with essential
roles in their social life. In Deuterostoma, sialic acids present at the outermost positions of …

Effects of nondigestible oligosaccharides on obesity

Q Nie, H Chen, J Hu, H Tan, S Nie… - Annual Review of Food …, 2020 - annualreviews.org
Obesity is a major public health concern that has almost reached the level of pandemic and
is rapidly progressing. The gut microbiota has emerged as a crucial regulator involved in the …

Glycosyltransferase Co‐Immobilization for Natural Product Glycosylation: Cascade Biosynthesis of the C‐Glucoside Nothofagin with Efficient Reuse of Enzymes

H Liu, G Tegl, B Nidetzky - Advanced Synthesis & Catalysis, 2021 - Wiley Online Library
Sugar nucleotide‐dependent (Leloir) glycosyltransferases are synthetically important for
oligosaccharides and small molecule glycosides. Their practical use involves one‐pot …

Natural and engineered transglycosylases: Green tools for the enzyme-based synthesis of glycoproducts

C Moulis, D Guieysse, S Morel, E Séverac… - Current opinion in …, 2021 - Elsevier
An increasing number of transglycosylase-based processes provide access to
oligosaccharides or glycoconjugates, some of them reaching performance levels compatible …