Fine-tuning cellular physiology in response to intracellular and environmental cues requires
precise temporal and spatial control of gene expression. High-resolution imaging …

Local translation regulates the axonal proteome, playing an important role in neuronal
wiring and axon maintenance. How axonal mRNAs are localized to specific subcellular sites …

Targeting of mRNAs to neuronal dendrites and axons plays an integral role in intracellular
signaling, development, and synaptic plasticity. Single-molecule imaging of mRNAs in …

Individual cells of the same phenotype are commonly viewed as identical functional units of
a tissue or organ. However, the deep sequencing of DNA and RNA from single cells …

Nascent proteins can be positioned rapidly at precise subcellular locations by local protein
synthesis (LPS) to facilitate localized growth responses. Axon arbor architecture, a major …

The immediate early gene Arc (also Arg3. 1) produces rapid changes in synaptic properties
that are linked to de novo translation. Here we develop a novel translation reporter that …

The proper regulation of translation is required for the expression of long-lasting synaptic
plasticity. A major site of translational control involves the phosphorylation of eukaryotic …

AMPA-type glutamate receptors mediate fast, excitatory neurotransmission in the brain, and
their concentrations at synapses are important determinants of synaptic strength. We …

Tau is a microtubule-associated protein, localizing mainly in the axon of mature neurons.
Phenotypic analysis of Tau knockout mice has revealed an impairment of synaptic plasticity …

RNA in cells is always associated with RNA-binding proteins that regulate all aspects of
RNA metabolism including RNA splicing, export from the nucleus, RNA localization, mRNA …