Natural products: an evolving role in future drug discovery
The therapeutic areas of infectious diseases and oncology have benefited from abundant
scaffold diversity in natural products, able to interact with many specific targets within the cell …
scaffold diversity in natural products, able to interact with many specific targets within the cell …
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections
Virus infection induces different cellular responses in infected cells. These include cellular
stress responses like autophagy and unfolded protein response (UPR). Both autophagy and …
stress responses like autophagy and unfolded protein response (UPR). Both autophagy and …
Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors
JY Park, HJ Yuk, HW Ryu, SH Lim, KS Kim… - Journal of enzyme …, 2017 - Taylor & Francis
The current study was designed to assess the inhibitory activity of Broussonetia papyrifera-
derived polyphenols against 3-chymotrypsin-like and papain-like coronavirus cysteine …
derived polyphenols against 3-chymotrypsin-like and papain-like coronavirus cysteine …
Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond
Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging
Zika virus, are an increasing and probably lasting global risk. This Review summarizes and …
Zika virus, are an increasing and probably lasting global risk. This Review summarizes and …
Potential antiviral action of alkaloids
Viral infections and outbreaks have become a major concern and are one of the main
causes of morbidity and mortality worldwide. The development of successful antiviral …
causes of morbidity and mortality worldwide. The development of successful antiviral …
Ten years of dengue drug discovery: progress and prospects
To combat neglected diseases, the Novartis Institute of Tropical Diseases (NITD) was
founded in 2002 through private–public funding from Novartis and the Singapore Economic …
founded in 2002 through private–public funding from Novartis and the Singapore Economic …
[HTML][HTML] Recent advances in antiviral drug development towards dengue virus
B Troost, JM Smit - Current opinion in virology, 2020 - Elsevier
Highlights•Evaluating drug efficacy, specificity and toxicity may help to develop an optimal
treatment regime for in vivo studies.•Measuring time to resolve viremia in vivo may help to …
treatment regime for in vivo studies.•Measuring time to resolve viremia in vivo may help to …
An adenosine nucleoside inhibitor of dengue virus
Dengue virus (DENV), a mosquito-borne flavivirus, is a major public health threat. The virus
poses risk to 2.5 billion people worldwide and causes 50 to 100 million human infections …
poses risk to 2.5 billion people worldwide and causes 50 to 100 million human infections …
In vitro and in silico anti-dengue activity of compounds obtained from Psidium guajava through bioprospecting
Background For decades, bioprospecting has proven to be useful for the identification of
compounds with pharmacological potential. Considering the great diversity of Colombian …
compounds with pharmacological potential. Considering the great diversity of Colombian …
Alkaloids as potential antivirals. A comprehensive review
Alkaloids are a diverse group of natural phytochemicals. These phytochemicals in plants
provide them protection against pests, and herbivorous organisms and also control their …
provide them protection against pests, and herbivorous organisms and also control their …