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Protein ensembles: how does nature harness thermodynamic fluctuations for life? The diverse functional roles of conformational ensembles in the cell
All soluble proteins populate conformational ensembles that together constitute the native
state. Their fluctuations in water are intrinsic thermodynamic phenomena, and the …
state. Their fluctuations in water are intrinsic thermodynamic phenomena, and the …
Is allostery an intrinsic property of all dynamic proteins?
Allostery involves coupling of conformational changes between two widely separated
binding sites. The common view holds that allosteric proteins are symmetric oligomers, with …
binding sites. The common view holds that allosteric proteins are symmetric oligomers, with …
[HTML][HTML] ESPEN micronutrient guideline
Background Trace elements and vitamins, named together micronutrients (MNs), are
essential for human metabolism. Recent research has shown the importance of MNs in …
essential for human metabolism. Recent research has shown the importance of MNs in …
A unified model of protein dynamics
Protein functions require conformational motions. We show here that the dominant
conformational motions are slaved by the hydration shell and the bulk solvent. The protein …
conformational motions are slaved by the hydration shell and the bulk solvent. The protein …
Normal mode analysis of biomolecular structures: functional mechanisms of membrane proteins
A polymer chain of N atoms enjoys 3N-6 internal degrees of freedom, which gives rise to
infinitely many conformations. Even a simple model of N) 100 atoms where bond lengths …
infinitely many conformations. Even a simple model of N) 100 atoms where bond lengths …
Myoglobin: an essential hemoprotein in striated muscle
Myoglobin is a cytoplasmic hemoprotein, expressed solely in cardiac myocytes and
oxidative skeletal muscle fibers, that reversibly binds O2 by its heme residue, a porphyrin …
oxidative skeletal muscle fibers, that reversibly binds O2 by its heme residue, a porphyrin …
XFELs for structure and dynamics in biology
JCH Spence - IUCrJ, 2017 - journals.iucr.org
The development and application of the free-electron X-ray laser (XFEL) to structure and
dynamics in biology since its inception in 2009 are reviewed. The research opportunities …
dynamics in biology since its inception in 2009 are reviewed. The research opportunities …
Automatic discovery of metastable states for the construction of Markov models of macromolecular conformational dynamics
To meet the challenge of modeling the conformational dynamics of biological
macromolecules over long time scales, much recent effort has been devoted to constructing …
macromolecules over long time scales, much recent effort has been devoted to constructing …
Slaving: solvent fluctuations dominate protein dynamics and functions
Protein motions are essential for function. Comparing protein processes with the dielectric
fluctuations of the surrounding solvent shows that they fall into two classes: nonslaved and …
fluctuations of the surrounding solvent shows that they fall into two classes: nonslaved and …
Multiscale nuclear magnetic relaxation dispersion of complex liquids in bulk and confinement
JP Korb - Progress in Nuclear Magnetic Resonance …, 2018 - Elsevier
The nuclear magnetic relaxation dispersion (NMRD) technique consists of measurement of
the magnetic-field dependence of the longitudinal nuclear-spin-lattice relaxation rate 1/T 1 …
the magnetic-field dependence of the longitudinal nuclear-spin-lattice relaxation rate 1/T 1 …