Rude mechanicals in brain haemodynamics: non-neural actors that influence blood flow
Fluctuations in blood oxygenation and flow are widely used to infer brain activity during
resting-state functional magnetic resonance imaging (fMRI). However, there are strong …
resting-state functional magnetic resonance imaging (fMRI). However, there are strong …
nNOS-expressing interneurons control basal and behaviorally evoked arterial dilation in somatosensory cortex of mice
Cortical neural activity is coupled to local arterial diameter and blood flow. However, which
neurons control the dynamics of cerebral arteries is not well understood. We dissected the …
neurons control the dynamics of cerebral arteries is not well understood. We dissected the …
The vascular conducted response in cerebral blood flow regulation
Despite recent advances in our understanding of the molecular and cellular mechanisms
behind vascular conducted responses (VCRs) in systemic arterioles, we still know very little …
behind vascular conducted responses (VCRs) in systemic arterioles, we still know very little …
[BOOK][B] Cerebral blood flow and metabolism: a quantitative approach
SJ Payne - 2018 - World Scientific
The human brain is possibly the most complex organ in existence. This complexity means
that it is capable of great feats, yet has ensured that it remains surprisingly poorly …
that it is capable of great feats, yet has ensured that it remains surprisingly poorly …
KIR channels tune electrical communication in cerebral arteries
The conducted vasomotor response reflects electrical communication in the arterial wall and
the distance signals spread is regulated by three factors including resident ion channels …
the distance signals spread is regulated by three factors including resident ion channels …
Integrative model of coronary flow in anatomically based vasculature under myogenic, shear, and metabolic regulation
Coronary blood flow is regulated to match the oxygen demand of myocytes in the heart wall.
Flow regulation is essential to meet the wide range of cardiac workload. The blood flows …
Flow regulation is essential to meet the wide range of cardiac workload. The blood flows …
[HTML][HTML] The conducted vascular response as a mediator of hypercapnic cerebrovascular reactivity: a modelling study
A Daher, S Payne - Computers in Biology and Medicine, 2024 - Elsevier
It is well established that the cerebral blood flow (CBF) shows exquisite sensitivity to
changes in the arterial blood partial pressure of CO 2 (P a, CO 2), which is reflected by an …
changes in the arterial blood partial pressure of CO 2 (P a, CO 2), which is reflected by an …
Biophysical properties of microvascular endothelium: Requirements for initiating and conducting electrical signals
A Kapela, EJ Behringer, SS Segal… - …, 2018 - Wiley Online Library
Objective Electrical signaling along the endothelium underlies spreading vasodilation and
blood flow control. We use mathematical modeling to determine the electrical properties of …
blood flow control. We use mathematical modeling to determine the electrical properties of …
Less is more: minimal expression of myoendothelial gap junctions optimizes cell–cell communication in virtual arterioles
Key points Electrical signalling in blood vessels is important in acute and long‐term flow
regulation. As myoendothelial gap junctions (MEGJs) provide electrical contacts between …
regulation. As myoendothelial gap junctions (MEGJs) provide electrical contacts between …
An assessment of KIR channel function in human cerebral arteries
In the rodent cerebral circulation, inward rectifying K+ (KIR) channels set resting tone and
the distance over which electrical phenomena spread along the arterial wall. The present …
the distance over which electrical phenomena spread along the arterial wall. The present …