Recent advances in cryo-electron microscopy have marked only the beginning of the
potential of this technique. To bring structure into cell biology, the modality of cryo-electron …

The artificial intelligence program AlphaFold 2 is revolutionizing the field of protein structure
determination as it accurately predicts the 3D structure of two thirds of the human proteome …

We present a new approach for macromolecular structure determination from multiple
particles in electron cryo-tomography (cryo-ET) data sets. Whereas existing subtomogram …

In situ cryo electron tomography of cryo focused ion beam milled samples has emerged in
recent years as a powerful technique for structural studies of macromolecular complexes in …

Coronaviruses remodel the intracellular host membranes during replication, forming double-
membrane vesicles (DMVs) to accommodate viral RNA synthesis and modifications,. SARS …

Cryo-electron tomography (cryo-ET) enables molecular-resolution 3D imaging of complex
biological specimens such as viral particles, cellular sections and, in some cases, whole …

Carboxysomes are a family of bacterial microcompartments in cyanobacteria and
chemoautotrophs. They encapsulate Ribulose 1, 5-bisphosphate carboxylase/oxygenase …

Cryo-electron tomography allows the routine visualization of cellular landscapes in three
dimensions at nanometer-range resolutions. When combined with single-particle …

Membranes are essential for life. They act as semi-permeable boundaries that define cells
and organelles. In addition, their surfaces actively participate in biochemical reaction …

Methane-oxidizing bacteria play a central role in greenhouse gas mitigation and have
potential applications in biomanufacturing. Their primary metabolic enzyme, particulate …