Recent innovations in differentiating cardiomyocytes from human induced pluripotent stem
cells (hiPSCs) have unlocked a viable path to creating in vitro cardiac models. Currently …

Cardiovascular diseases are the leading cause of death worldwide. Several strategies–
small molecules, gene therapy, surgeries, cardiac rehabilitation–have been developed to …

Introduction: The development of patient-specific induced pluripotent stem cell-derived
cardiomyocytes (iPSC-CMs) offers an opportunity to study genotype-phenotype correlation …

The in vitro generation of human cardiomyocytes derived from induced pluripotent stem cells
(iPSC) is of great importance for cardiac disease modeling, drug-testing applications and for …

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) constitute an appealing
tool for drug discovery, disease modeling, and cardiotoxicity screening. However, their …

Heart disease remains the leading cause of death worldwide (World Health Organization,
nd). In response to this societal burden, scientific funding agencies and researchers have …

Controlling cellular shape with micropatterning extracellular matrix (ECM) proteins on
hydrogels has been shown to improve the reproducibility of the cell structure, enhancing our …

Background and objective Knowledge of electromechanical coupling in cardiomyocyte and
how it is influenced by various pathophysiological factors is fundamental to understanding …

Advancing human induced pluripotent stem cell derived cardiomyocyte (hiPSC-CM)
technology will lead to significant progress ranging from disease modeling, to drug …

Regular spatial patterns are ubiquitous forms of organization in nature. In animals, regular
patterns can be found from the cellular scale to the tissue scale, and from early stages of …