Cellular cytotoxicity, the ability to kill other cells, is an important effector mechanism of the
immune system to combat viral infections and cancer. Cytotoxic T cells and natural killer …

Induction of cell death is inexorably linked with cancer therapy, but this can also initiate
wound-healing processes that have been linked to cancer progression and therapeutic …

Cytotoxic T cells (CTLs) are the main cellular mediators of the adaptive immune defenses
against intracellular pathogens and malignant cells. Upon recognition of specific antigen on …

Natural Killer (NK) cells are innate immune cells that play a pivotal role as first line
defenders in the anti-tumor response. To prevent tumor development, NK cells are …

Extracellular vesicles (EVs) are fundamental for proper physiological functioning of
multicellular organisms. By shuttling nucleic acids and proteins between cells, EVs regulate …

NK cell-mediated cytotoxicity is a critical element of our immune system required for
protection from microbial infections and cancer. NK cells bind to and eliminate infected or …

Immune synapses are formed between immune cells to facilitate communication and
coordinate the immune response. The reorganization of receptors involved in recognition …

Natural killer (NK) cells are cytotoxic lymphocytes that are present in the circulation but also
in many organs including spleen and gut, where they play an important role in the defense …

Until the last decade, chemotherapy was the standard treatment for metastatic cutaneous
melanoma, even with poor results. The introduction of immune checkpoints inhibitors (ICIs) …

The immune synapse is a very important but often transient site for secretion between
immune cells. How secretion is controlled in a coordinated fashion at the synapse is a …