Conspectus Are all protein interactions fully optimized? Do suboptimal interactions
compromise specificity? What is the functional impact of frustration? Why does evolution not …

A popular and successful strategy in semi-rational design of protein stability is the use of
evolutionary information encapsulated in homologous protein sequences. Consensus …

The protein frustratometer is an energy landscape theory-inspired algorithm that aims at
localizing and quantifying the energetic frustration present in protein molecules. Frustration …

Owing to their outstanding performances in molecular recognition, antibodies are
extensively used in research and applications in molecular biology, biotechnology and …

The hydrophobic effect is a major driving force in protein folding. A complete understanding
of this effect requires the description of the conformational states of water and protein …

Natural protein molecules are exceptional polymers. Encoded in apparently random strings
of amino-acids, these objects perform clear physical tasks that are rare to find by simple …

Biologics, such as antibodies and enzymes, are crucial in research, biotechnology,
diagnostics, and therapeutics. Often, biologics with suitable functionality are discovered, but …

Evolutionary pressure for protein function leads to unavoidable sampling of conformational
states that are at risk of misfolding and aggregation. The resulting tension between …

Intrinsically disordered proteins (IDPs), which are expected to be largely unstructured under
physiological conditions, make up a large fraction of eukaryotic proteins. Molecular …

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. The outbreak of CHIKV
infection has been seen in many tropical and subtropical regions of the biosphere. Current …