Redesigning of cell-penetrating peptides to improve their efficacy as a drug delivery system
Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of
compounds into cells. Since the discovery of the first members of this peptide family, many …
compounds into cells. Since the discovery of the first members of this peptide family, many …
Photoallosteric polymersomes toward on‐demand drug delivery and multimodal cancer immunotherapy
Y Zheng, Y Liu, Z Wu, C Peng, Z Wang… - Advanced …, 2023 - Wiley Online Library
Allosteric transitions can modulate the self‐assembly and biological function of proteins. It
remains, however, tremendously challenging to design synthetic allosteric polymeric …
remains, however, tremendously challenging to design synthetic allosteric polymeric …
Enhanced photodynamic cancer treatment by mitochondria‐targeting and brominated near‐infrared fluorophores
A noninvasive and selective therapy, photodynamic therapy (PDT) is widely researched in
clinical fields; however, the lower efficiency of PDT can induce unexpected side effects …
clinical fields; however, the lower efficiency of PDT can induce unexpected side effects …
Immunogenic cell death inducing fluorinated mitochondria‐disrupting helical polypeptide synergizes with PD‐L1 immune checkpoint blockade
Immunogenic cell death (ICD) is distinguished by the release of tumor‐associated antigens
(TAAs) and danger‐associated molecular patterns (DAMPs). This cell death has been …
(TAAs) and danger‐associated molecular patterns (DAMPs). This cell death has been …
Conformation-directed micelle-to-vesicle transition of cholesterol-decorated polypeptide triggered by oxidation
H Liu, R Wang, J Wei, C Cheng, Y Zheng… - Journal of the …, 2018 - ACS Publications
Hierarchical self-assembly of synthetic polypeptides has attracted increasing interests due to
its protein-mimetic structure and great potential in nanotechnology and biomedical …
its protein-mimetic structure and great potential in nanotechnology and biomedical …
Stimuli-responsive polypeptides for biomedical applications
Stimuli-responsive polypeptides have gained attention because desirable bioactive
properties can be easily imparted to them while kee** their biocompatibility and …
properties can be easily imparted to them while kee** their biocompatibility and …
Prevented Cell Clusters' Migration Via Microdot Biomaterials for Inhibiting Scar Adhesion
Y Zhuang, F Lin, L **ang, Z Cai, F Wang… - Advanced …, 2024 - Wiley Online Library
Cluster‐like collective cell migration of fibroblasts is one of the main factors of adhesion in
injured tissues. In this research, a microdot biomaterial system is constructed using α‐helical …
injured tissues. In this research, a microdot biomaterial system is constructed using α‐helical …
Development of apoptosis-inducing polypeptide via simultaneous mitochondrial membrane disruption and Ca2+ delivery
Mitochondria are the primary organelle of regulating apoptosis, and intracellular calcium
ions are a key component of pro-apoptosis induction. Herein, we report an artificial …
ions are a key component of pro-apoptosis induction. Herein, we report an artificial …
Synergistic cancer starvation therapy via mitochondria targeting cell penetrating polypeptide
Aberrant cancer metabolism has been recognized to be an attractive target for cancer
treatments. However, inhibition of a single metabolic pathway has limited efficacy. In this …
treatments. However, inhibition of a single metabolic pathway has limited efficacy. In this …
Development of an Intracellular Nitric Oxide-Donating Cell-Penetrating Polypeptide as an Immunogenic Cell Death Inducer
Recently, nitric oxide (NO) has been shown to induce immunogenic cell death (ICD) in tumor
cells through endoplasmic reticulum (ER) stress and mitochondrial outer membrane …
cells through endoplasmic reticulum (ER) stress and mitochondrial outer membrane …