Redesigning of cell-penetrating peptides to improve their efficacy as a drug delivery system

I Szabó, M Yousef, D Soltész, C Bató, G Mező… - Pharmaceutics, 2022 - mdpi.com
Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of
compounds into cells. Since the discovery of the first members of this peptide family, many …

Photoallosteric polymersomes toward on‐demand drug delivery and multimodal cancer immunotherapy

Y Zheng, Y Liu, Z Wu, C Peng, Z Wang… - Advanced …, 2023 - Wiley Online Library
Allosteric transitions can modulate the self‐assembly and biological function of proteins. It
remains, however, tremendously challenging to design synthetic allosteric polymeric …

Enhanced photodynamic cancer treatment by mitochondria‐targeting and brominated near‐infrared fluorophores

I Noh, DY Lee, H Kim, CU Jeong, Y Lee… - Advanced …, 2018 - Wiley Online Library
A noninvasive and selective therapy, photodynamic therapy (PDT) is widely researched in
clinical fields; however, the lower efficiency of PDT can induce unexpected side effects …

Immunogenic cell death inducing fluorinated mitochondria‐disrupting helical polypeptide synergizes with PD‐L1 immune checkpoint blockade

SD Jeong, BK Jung, HM Ahn, DY Lee, JH Ha… - Advanced …, 2021 - Wiley Online Library
Immunogenic cell death (ICD) is distinguished by the release of tumor‐associated antigens
(TAAs) and danger‐associated molecular patterns (DAMPs). This cell death has been …

Conformation-directed micelle-to-vesicle transition of cholesterol-decorated polypeptide triggered by oxidation

H Liu, R Wang, J Wei, C Cheng, Y Zheng… - Journal of the …, 2018 - ACS Publications
Hierarchical self-assembly of synthetic polypeptides has attracted increasing interests due to
its protein-mimetic structure and great potential in nanotechnology and biomedical …

Stimuli-responsive polypeptides for biomedical applications

DY Lee, NS Re**old, SD Jeong, YC Kim - Polymers, 2018 - mdpi.com
Stimuli-responsive polypeptides have gained attention because desirable bioactive
properties can be easily imparted to them while kee** their biocompatibility and …

Prevented Cell Clusters' Migration Via Microdot Biomaterials for Inhibiting Scar Adhesion

Y Zhuang, F Lin, L **ang, Z Cai, F Wang… - Advanced …, 2024 - Wiley Online Library
Cluster‐like collective cell migration of fibroblasts is one of the main factors of adhesion in
injured tissues. In this research, a microdot biomaterial system is constructed using α‐helical …

Development of apoptosis-inducing polypeptide via simultaneous mitochondrial membrane disruption and Ca2+ delivery

JH Ha, DY Lee, SH Lee, CO Yun, YC Kim - Biomaterials, 2019 - Elsevier
Mitochondria are the primary organelle of regulating apoptosis, and intracellular calcium
ions are a key component of pro-apoptosis induction. Herein, we report an artificial …

Synergistic cancer starvation therapy via mitochondria targeting cell penetrating polypeptide

H Nam, YC Kim - Journal of Industrial and Engineering Chemistry, 2021 - Elsevier
Aberrant cancer metabolism has been recognized to be an attractive target for cancer
treatments. However, inhibition of a single metabolic pathway has limited efficacy. In this …

Development of an Intracellular Nitric Oxide-Donating Cell-Penetrating Polypeptide as an Immunogenic Cell Death Inducer

N Kim, S Lee, H Park, S Kim, YC Kim - ACS Applied Bio Materials, 2024 - ACS Publications
Recently, nitric oxide (NO) has been shown to induce immunogenic cell death (ICD) in tumor
cells through endoplasmic reticulum (ER) stress and mitochondrial outer membrane …