Anti‐ageing active ingredients from herbs and nutraceuticals used in traditional Chinese medicine: pharmacological mechanisms and implications for drug discovery
CY Shen, JG Jiang, L Yang… - British Journal of …, 2017 - Wiley Online Library
Ageing, an unanswered question in the medical field, is a multifactorial process that results
in a progressive functional decline in cells, tissues and organisms. Although it is impossible …
in a progressive functional decline in cells, tissues and organisms. Although it is impossible …
Molecular insights into the premature aging disease progeria
Hutchinson–Gilford progeria syndrome (HGPS) is an extremely rare premature aging
disease presenting many features resembling the normal aging process. HGPS patients die …
disease presenting many features resembling the normal aging process. HGPS patients die …
Effect of thymol and resveratrol administered with candy or syrup on the development of Nosema ceranae and on the longevity of honeybees (Apis mellifera L.) in …
The aim of this study was to evaluate the effect of thymol and resveratrol administered in two
different formulation modes (candy and syrup) on the development of Nosema ceranae and …
different formulation modes (candy and syrup) on the development of Nosema ceranae and …
MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer
U Thirumurthi, J Shen, W **a, AM LaBaff, Y Wei… - Science …, 2014 - science.org
Sirtuin 6 (SIRT6) is associated with longevity and is also a tumor suppressor. Identification of
molecular regulators of SIRT6 might enable its activation therapeutically in cancer patients …
molecular regulators of SIRT6 might enable its activation therapeutically in cancer patients …
Senolytic and senomorphic secondary metabolites as therapeutic agents in Drosophila melanogaster models of Parkinson's disease
SJ Miller, RY Darji, S Walaieh, JA Lewis… - Frontiers in …, 2023 - frontiersin.org
Drosophila melanogaster is a valuable model organism for a wide range of biological
exploration. The well-known advantages of D. melanogaster include its relatively simple …
exploration. The well-known advantages of D. melanogaster include its relatively simple …
Vitis amurensis Rupr: A review of chemistry and pharmacology
Q Chen, L Diao, H Song, X Zhu - Phytomedicine, 2018 - Elsevier
Abstract Purpose Vitis amurensis Rupr. from the family Vitaceae, is a grape species native to
the Asian continent. It is a highly attractive plant, used widely worldwide. It has been used for …
the Asian continent. It is a highly attractive plant, used widely worldwide. It has been used for …
Evidence supporting a mechanistic role of sirtuins in mood and metabolic disorders
Sirtuins are NAD+-dependent histone deacetylases that play essential roles in cell survival,
energy metabolism, inflammation, and aging; therefore, sirtuins are potential therapeutic …
energy metabolism, inflammation, and aging; therefore, sirtuins are potential therapeutic …
Small berries as health-promoting ingredients: a review on anti-aging effects and mechanisms in Caenorhabditis elegans
R Li, M Tao, T Xu, S Pan, X Xu, T Wu - Food & function, 2022 - pubs.rsc.org
Aging is an inevitable, irreversible, and complex process of damage accumulation and
functional decline, increasing the risk of various chronic diseases. However, for now no drug …
functional decline, increasing the risk of various chronic diseases. However, for now no drug …
Low‐Molecular Weight Compounds that Extend the Chronological Lifespan of Yeasts, Saccharomyces cerevisiae, and Schizosaccharomyces pombe
H Ohtsuka, T Shimasaki, H Aiba - Advanced Biology, 2024 - Wiley Online Library
Yeast is an excellent model organism for research for regulating aging and lifespan, and the
studies have made many contributions to date, including identifying various factors and …
studies have made many contributions to date, including identifying various factors and …
Synthesis of polyhydroxylated ester analogs of the stilbene resveratrol using decarbonylative Heck couplings
MB Andrus, J Liu - Tetrahedron letters, 2006 - Elsevier
Protected 3, 5-hydroxy-benzoyl chlorides 3 were coupled with styrenes 4 to give
hydroxylated stilbenes, analogs of resveratrol, an important antioxidant disease preventative …
hydroxylated stilbenes, analogs of resveratrol, an important antioxidant disease preventative …