Anti‐ageing active ingredients from herbs and nutraceuticals used in traditional Chinese medicine: pharmacological mechanisms and implications for drug discovery

CY Shen, JG Jiang, L Yang… - British Journal of …, 2017 - Wiley Online Library
Ageing, an unanswered question in the medical field, is a multifactorial process that results
in a progressive functional decline in cells, tissues and organisms. Although it is impossible …

Molecular insights into the premature aging disease progeria

S Vidak, R Foisner - Histochemistry and cell biology, 2016 - Springer
Hutchinson–Gilford progeria syndrome (HGPS) is an extremely rare premature aging
disease presenting many features resembling the normal aging process. HGPS patients die …

Effect of thymol and resveratrol administered with candy or syrup on the development of Nosema ceranae and on the longevity of honeybees (Apis mellifera L.) in …

C Costa, M Lodesani, L Maistrello - Apidologie, 2010 - apidologie.org
The aim of this study was to evaluate the effect of thymol and resveratrol administered in two
different formulation modes (candy and syrup) on the development of Nosema ceranae and …

MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer

U Thirumurthi, J Shen, W **a, AM LaBaff, Y Wei… - Science …, 2014 - science.org
Sirtuin 6 (SIRT6) is associated with longevity and is also a tumor suppressor. Identification of
molecular regulators of SIRT6 might enable its activation therapeutically in cancer patients …

Senolytic and senomorphic secondary metabolites as therapeutic agents in Drosophila melanogaster models of Parkinson's disease

SJ Miller, RY Darji, S Walaieh, JA Lewis… - Frontiers in …, 2023 - frontiersin.org
Drosophila melanogaster is a valuable model organism for a wide range of biological
exploration. The well-known advantages of D. melanogaster include its relatively simple …

Vitis amurensis Rupr: A review of chemistry and pharmacology

Q Chen, L Diao, H Song, X Zhu - Phytomedicine, 2018 - Elsevier
Abstract Purpose Vitis amurensis Rupr. from the family Vitaceae, is a grape species native to
the Asian continent. It is a highly attractive plant, used widely worldwide. It has been used for …

Evidence supporting a mechanistic role of sirtuins in mood and metabolic disorders

A Alageel, J Tomasi, C Tersigni, E Brietzke… - Progress in Neuro …, 2018 - Elsevier
Sirtuins are NAD+-dependent histone deacetylases that play essential roles in cell survival,
energy metabolism, inflammation, and aging; therefore, sirtuins are potential therapeutic …

Small berries as health-promoting ingredients: a review on anti-aging effects and mechanisms in Caenorhabditis elegans

R Li, M Tao, T Xu, S Pan, X Xu, T Wu - Food & function, 2022 - pubs.rsc.org
Aging is an inevitable, irreversible, and complex process of damage accumulation and
functional decline, increasing the risk of various chronic diseases. However, for now no drug …

Low‐Molecular Weight Compounds that Extend the Chronological Lifespan of Yeasts, Saccharomyces cerevisiae, and Schizosaccharomyces pombe

H Ohtsuka, T Shimasaki, H Aiba - Advanced Biology, 2024 - Wiley Online Library
Yeast is an excellent model organism for research for regulating aging and lifespan, and the
studies have made many contributions to date, including identifying various factors and …

Synthesis of polyhydroxylated ester analogs of the stilbene resveratrol using decarbonylative Heck couplings

MB Andrus, J Liu - Tetrahedron letters, 2006 - Elsevier
Protected 3, 5-hydroxy-benzoyl chlorides 3 were coupled with styrenes 4 to give
hydroxylated stilbenes, analogs of resveratrol, an important antioxidant disease preventative …