Transforming growth factor (TGF)-β is a multifunctional cytokine expressed by almost every
tissue and cell type. The signal transduction of TGF-β can stimulate diverse cellular …

The influence of the microenvironment on tumour progression is becoming clearer. In this
Review we address the role of an essential signalling pathway, that of transforming growth …

In human tissues, normal homeostasis requires intricately balanced interactions between
cells and the network of secreted proteins known as the extracellular matrix. These …

Epithelial and hematopoietic cells have a high turnover and their progenitor cells divide
continuously, making them prime targets for genetic and epigenetic changes that lead to cell …

The transforming growth factor β (TGFβ) pathway occupies a central position in the signaling
networks that control the growth, differentiation, and final fate of metazoan cells. Over the …

Biologic machines need brakes, and the nature and fidelity of their operation cannot be
unraveled without some prior understanding of how accelerators work. The discoveD] of …

As the tale of p53 unfolds, it becomes ever more intriguing. Although our understanding of
the critical and complex roles played by p53 is progressing rapidly, new findings continue to …

Transforming growth factor beta (TGF-β) is a ubiquitous and essential regulator of cellular
and physiologic processes including proliferation, differentiation, migration, cell survival …

Transforming growth factor-β (TGF-β) is a secreted polypeptide that signals via receptor
serine/threonine kinases and intracellular Smad effectors. TGF-β inhibits proliferation and …

Phosphotyrosine phosphatases are critical negative or positive regulators in the intracellular
signalling pathways that result in growth-factor-specific cell responses such as mitosis …