Dopamine D2-autoreceptors play a key role in regulating the activity of dopamine neurons
and control the synthesis, release and uptake of dopamine. These G i/o-coupled inhibitory …

The degeneration of mesencephalic dopaminergic neurons that innervate the basal ganglia
is responsible for the cardinal motor symptoms of Parkinson's disease (PD). It has been …

Intracellular recordings were obtained from directly identified rat nigral dopamine cells in
vivo. This identification was based on an increase in glyoxylic acid-induced catecholamine …

The previous editions of The Rat Nervous System were indispensable guides for those
working on the rat and mouse as experimental models. The fourth edition enhances this …

This review covers recent developments in the cellular neurophysiology of retrograde
signaling in the mammalian central nervous system. Normally at a chemical synapse a …

It was long thought that no new neurons are added to the adult brain. Similarly,
neurotransmitter signaling was primarily associated with communication between …

Dopamine (DA) is a key transmitter in the basal ganglia, yet DA transmission does not
conform to several aspects of the classic synaptic doctrine. Axonal DA release occurs …

1. Intracellular recordings were made from neurones in the substantia nigra zona compacta
in slices of rat mesencephalon in vitro. The majority of neurones fired action potentials …

Nigrostriatal dopaminergic neurons play an essential role in the central regulation of motor
functions. These functions are initiated through the release of dopamine from axon terminals …

Synchronous activation of dopamine neurons, for instance upon presentation of an
unexpected rewarding stimulus, results in the release of dopamine from both terminals in …