The gastrointestinal tract harbors numerous commensal bacteria, referred to as the
microbiota, that benefit host health by digesting dietary components and eliminating …

Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …

Cancers are able to grow by subverting immune suppressive pathways, to prevent the
malignant cells as being recognized as dangerous or foreign. This mechanism prevents the …

The enzymatic activities of CD39 and CD73 play strategic roles in calibrating the duration,
magnitude, and chemical nature of purinergic signals delivered to immune cells through the …

Stimulation of almost all mammalian cell types leads to the release of cellular ATP and
autocrine feedback through a diverse array of purinergic receptors. Depending on the types …

This review article provides a historical perspective on the role of purinergic signalling in the
regulation of various subsets of immune cells from early discoveries to current …

Extracellular ATP is a danger signal released by dying and damaged cells, and it functions
as an immunostimulatory signal that promotes inflammation. However, extracellular …

Adenosine is an endogenously released purine nucleoside that signals via 4 widely
expressed G protein-coupled receptors: A1, A2A, A2B, and A3. In the setting of inflammation …

BACKGROUND & AIMS: Adenosine mediates immune suppression and is generated by the
ectonucleotidases CD39 (ENTPD1) and CD73 that are expressed on vascular endothelial …

The A3 adenosine receptor (A3AR) subtype is a novel, promising therapeutic target for
inflammatory diseases, such as rheumatoid arthritis (RA) and psoriasis, as well as liver …