CD44, a non-kinase transmembrane glycoprotein, is overexpressed in several cell types
including cancer stem cells and frequently shows alternative spliced variants that are …

The Notch signaling pathway plays an essential role in a wide variety of biological
processes including cell fate determination of vascular endothelial cells and the regulation …

Abstract CD44/CD24 and ALDH1 are widely used cancer stem cell (CSC) markers in breast
cancer. However, their expression is not always consistent even in the same subtype of …

Both hereditary and sporadic breast cancer are suggested to develop from a stem cell
subcomponent retaining most key stem cell properties but with dysregulation of self-renewal …

The primary reason for high mortality rates among cancer patients is metastasis, where
tumor cells migrate through the bloodstream from the original site to other parts of the body …

Cancer stem cell population is a subset of cells capable of dictating invasion, metastasis,
heterogeneity, and therapeutic resistance in tumours. Eradication of this rare population is a …

Recent evidence suggests that enhanced aldehyde dehydrogenase (ALDH) activity is a
hallmark of cancer stem cells (CSC) measurable by the aldefluor assay. ALDH1A1, one of …

The hypothesis that cancer is driven by tumour-initiating cells (popularly known as cancer
stem cells) has recently attracted a great deal of attention, owing to the promise of a novel …

Metastatic growth in breast cancer (BC) has been proposed as an exclusive property of
cancer stem cells (CSCs). However, formal proof of their identity as cells of origin of …

The cancer stem cell (CSC) model does not imply that tumours are generated from
transformed tissue stem cells. The target of transformation could be a tissue stem cell, a …