Modulating biomolecular condensates: a novel approach to drug discovery

DM Mitrea, M Mittasch, BF Gomes, IA Klein… - Nature Reviews Drug …, 2022 - nature.com
In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …

Phase separation in viral infections

H Li, C Ernst, M Kolonko-Adamska… - Trends in …, 2022 - cell.com
Viruses rely on the reprogramming of cellular processes to enable efficient viral replication;
this often requires subcompartmentalization within the host cell. Liquid–liquid phase …

Liquid phase partitioning in virus replication: observations and opportunities

C Wu, AS Holehouse, DW Leung… - Annual Review of …, 2022 - annualreviews.org
Viruses frequently carry out replication in specialized compartments within cells. The effect
of these structures on virus replication is poorly understood. Recent research supports …

Cryo-electron tomography: the resolution revolution and a surge of in situ virological discoveries

Y Hong, Y Song, Z Zhang, S Li - Annual Review of Biophysics, 2023 - annualreviews.org
The recent proliferation of cryo-electron tomography (cryo-ET) techniques has led to the cryo-
ET resolution revolution. Meanwhile, significant efforts have been made to improve the …

Phase separation by the SARS-CoV-2 nucleocapsid protein: Consensus and open questions

SM Cascarina, ED Ross - Journal of Biological Chemistry, 2022 - ASBMB
In response to the recent SARS-CoV-2 pandemic, a number of labs across the world have
reallocated their time and resources to better our understanding of the virus. For some …

Viroplasms: assembly and functions of rotavirus replication factories

G Papa, A Borodavka, U Desselberger - Viruses, 2021 - mdpi.com
Viroplasms are cytoplasmic, membraneless structures assembled in rotavirus (RV)-infected
cells, which are intricately involved in viral replication. Two virus-encoded, non-structural …

Biomolecular condensates as novel antiviral targets

EW Martin, C Iserman, B Olety, DM Mitrea… - Journal of Molecular …, 2024 - Elsevier
Viral infections pose a significant health risk worldwide. There is a pressing need for more
effective antiviral drugs to combat emerging novel viruses and the reemergence of …

When liquid-liquid phase separation meets viral infections

W Wei, L Bai, B Yan, W Meng, H Wang, J Zhai… - Frontiers in …, 2022 - frontiersin.org
Eukaryotic cells have both membranous and membraneless organelles. While the formation
mechanism of membranous organelles is well understood, the formation mechanism of …

Defining basic rules for hardening influenza A virus liquid condensates

TA Etibor, S Vale-Costa, S Sridharan, D Brás, I Becher… - Elife, 2023 - elifesciences.org
In biological systems, liquid and solid-like biomolecular condensates may contain the same
molecules but their behaviour, including movement, elasticity, and viscosity, is different on …

A viral biomolecular condensate coordinates assembly of progeny particles

M Charman, N Grams, N Kumar, E Halko, JM Dybas… - Nature, 2023 - nature.com
Biomolecular condensates formed by phase separation can compartmentalize and regulate
cellular processes,. Emerging evidence has suggested that membraneless subcellular …