Modulating biomolecular condensates: a novel approach to drug discovery
In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …
been reported to play key roles in many cellular functions by compartmentalizing specific …
Phase separation in viral infections
Viruses rely on the reprogramming of cellular processes to enable efficient viral replication;
this often requires subcompartmentalization within the host cell. Liquid–liquid phase …
this often requires subcompartmentalization within the host cell. Liquid–liquid phase …
Liquid phase partitioning in virus replication: observations and opportunities
Viruses frequently carry out replication in specialized compartments within cells. The effect
of these structures on virus replication is poorly understood. Recent research supports …
of these structures on virus replication is poorly understood. Recent research supports …
Cryo-electron tomography: the resolution revolution and a surge of in situ virological discoveries
Y Hong, Y Song, Z Zhang, S Li - Annual Review of Biophysics, 2023 - annualreviews.org
The recent proliferation of cryo-electron tomography (cryo-ET) techniques has led to the cryo-
ET resolution revolution. Meanwhile, significant efforts have been made to improve the …
ET resolution revolution. Meanwhile, significant efforts have been made to improve the …
Phase separation by the SARS-CoV-2 nucleocapsid protein: Consensus and open questions
In response to the recent SARS-CoV-2 pandemic, a number of labs across the world have
reallocated their time and resources to better our understanding of the virus. For some …
reallocated their time and resources to better our understanding of the virus. For some …
Viroplasms: assembly and functions of rotavirus replication factories
Viroplasms are cytoplasmic, membraneless structures assembled in rotavirus (RV)-infected
cells, which are intricately involved in viral replication. Two virus-encoded, non-structural …
cells, which are intricately involved in viral replication. Two virus-encoded, non-structural …
Biomolecular condensates as novel antiviral targets
Viral infections pose a significant health risk worldwide. There is a pressing need for more
effective antiviral drugs to combat emerging novel viruses and the reemergence of …
effective antiviral drugs to combat emerging novel viruses and the reemergence of …
When liquid-liquid phase separation meets viral infections
W Wei, L Bai, B Yan, W Meng, H Wang, J Zhai… - Frontiers in …, 2022 - frontiersin.org
Eukaryotic cells have both membranous and membraneless organelles. While the formation
mechanism of membranous organelles is well understood, the formation mechanism of …
mechanism of membranous organelles is well understood, the formation mechanism of …
Defining basic rules for hardening influenza A virus liquid condensates
In biological systems, liquid and solid-like biomolecular condensates may contain the same
molecules but their behaviour, including movement, elasticity, and viscosity, is different on …
molecules but their behaviour, including movement, elasticity, and viscosity, is different on …
A viral biomolecular condensate coordinates assembly of progeny particles
Biomolecular condensates formed by phase separation can compartmentalize and regulate
cellular processes,. Emerging evidence has suggested that membraneless subcellular …
cellular processes,. Emerging evidence has suggested that membraneless subcellular …