Drug delivery devices are promising tools in the pharmaceutical field, as they are able to
maximize the therapeutic effects of the delivered drug while minimizing the undesired side …

Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

Cell migration regulates diverse (patho) physiological processes, including cancer
metastasis. According to the Osmotic Engine Model, polarization of NHE1 at the leading …

Cardiac electrophysiology models are among the most mature and well‐studied
mathematical models of biological systems. This maturity is bringing new challenges as …

Epithelial tissues sheath organs and electro-mechanically regulate ion and water transport
to regulate development, homeostasis, and hydrostatic organ pressure. Here, we …

Introduction Hypertrophic cardiomyopathy (HCM) is a cause of sudden arrhythmic death, but
the understanding of its pro-arrhythmic mechanisms and an effective pharmacological …

This is the second of the two White Papers from the fourth UC Davis Cardiovascular
Symposium Systems Approach to Understanding Cardiac Excitation–Contraction Coupling …

Aims Human atrial electrophysiology exhibits high inter-subject variability in both sinus
rhythm (SR) and chronic atrial fibrillation (cAF) patients. Variability is however rarely …

The traditional cardiac model-building paradigm involves constructing a composite model
using data collected from many cells. Equations are derived for each relevant cellular …

In cardiac electrophysiology, there exist many sources of inter-and intra-personal variability.
These include variability in conditions and environment, and genotypic and molecular …