The neurodevelopmental model of schizophrenia, which posits that the illness is the end
state of abnormal neurodevelopmental processes that started years before the illness onset …

After more than 100 years of research, the neuropathology of schizophrenia remains
unknown and this is despite the fact that both: Kraepelin, E., 1919/1971. Dementia praecox …

Despite significant gains in the fields of pediatric neuroimaging and developmental
neurobiology, surprisingly little is known about the develo** human brain or the neural …

Despite a hundred years' research, the neuropathology of schizophrenia remains obscure.
However, neither can the null hypothesis be sustained—that it is afunctional'psychosis, a …

Background: Previous investigations suggest that maltreated children with a diagnosis of
posttraumatic stress disorder (PTSD) evidence alterations of biological stress systems …

Neurodevelopmental models of schizophrenia that identify longitudinal precursors of illness
have been of great heuristic importance focusing most etiologic research over the past two …

David A. Lewis*‡ and Jeffrey A. Lieberman†‡* Departments of Psychiatry and Neuroscience
University of Pittsburgh School of Medicine this syndrome is increased as well. Recently …

The current diathesis-stress model of schizophrenia proposes that a genetic deficit creates a
predisposing vulnerability in the form of oversenstivity to stress. This model positions all …

This Practice Parameter reviews the literature on the assessment and treatment of children
and adolescents with schizophrenia. Early-onset schizophrenia is diagnosed using the …

The history of psychiatric research is filled with widely accepted etiologic and
pathophysiologic theories that eventually were proven wrong. The prevailing …