Obesity is characterized by increased adipose tissue mass and has been associated with a
strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public …

Insulin resistance is a main determinant in the development of type 2 diabetes mellitus and a
major cause of morbidity and mortality. The circadian timing system consists of a central …

Time-restricted feeding (TRF, animal-based studies) and time-restricted eating (TRE,
humans) are an emerging behavioral intervention approach based on the understanding of …

While diet-induced obesity has been exclusively attributed to increased caloric intake from
fat, animals fed a high-fat diet (HFD) ad libitum (ad lib) eat frequently throughout day and …

Humans, like all mammals, partition their daily behaviour into activity (wakefulness) and rest
(sleep) phases that differ largely in their metabolic requirements. The circadian clock …

The circadian clock, a highly specialized, hierarchical network of biological pacemakers,
directs and maintains proper rhythms in endocrine and metabolic pathways required for …

Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …

The mammalian circadian system, which is comprised of multiple cellular clocks located in
the organs and tissues, orchestrates their regulation in a hierarchical manner throughout the …

Transcriptional regulation of catabolic pathways is a central mechanism by which cells
respond to physiological cues to generate the energy required for anabolic pathways …

Circadian rhythms are 24-hr oscillations that control a variety of biological processes in
living systems, including two hallmarks of cancer, cell division and metabolism. Circadian …