Sequence-specific DNA binding Pyrrole–imidazole polyamides and their applications
Abstract Pyrrole–imidazole polyamides (Py–Im polyamides) are cell-permeable compounds
that bind to the minor groove of double-stranded DNA in a sequence-specific manner …
that bind to the minor groove of double-stranded DNA in a sequence-specific manner …
Programmable DNA-binding small molecules
Aberrant gene expression is responsible for a myriad of human diseases from infectious
diseases to cancer. Precise regulation of these genes via specific interactions with the DNA …
diseases to cancer. Precise regulation of these genes via specific interactions with the DNA …
Fluorescein redirects a ruthenium− octaarginine conjugate to the nucleus
CA Puckett, JK Barton - Journal of the American Chemical Society, 2009 - ACS Publications
The cellular uptake and localization of a Ru− octaarginine conjugate with and without an
appended fluorescein are compared. The inherent luminescence of the Ru (II) …
appended fluorescein are compared. The inherent luminescence of the Ru (II) …
Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist
Vascular endothelial growth factor (VEGF) and its receptors have been implicated as key
factors in tumor angiogenesis that are up-regulated by hypoxia. We evaluated the effects of …
factors in tumor angiogenesis that are up-regulated by hypoxia. We evaluated the effects of …
Allosteric modulation of DNA by small molecules
Many human diseases are caused by dysregulated gene expression. The oversupply of
transcription factors may be required for the growth and metastatic behavior of human …
transcription factors may be required for the growth and metastatic behavior of human …
Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and …
Herein, we describe the design of high affinity ligands that bind expanded rCUG and rCAG
repeat RNAs expressed in myotonic dystrophy type 1 (DM1) and spinocerebellar ataxia type …
repeat RNAs expressed in myotonic dystrophy type 1 (DM1) and spinocerebellar ataxia type …
Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders
Nuclear factor κB (NF-κB) is a transcription factor that regulates various aspects of immune
response, cell death, and differentiation as well as cancer. In this study we introduce the Py …
response, cell death, and differentiation as well as cancer. In this study we introduce the Py …
DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA· TTC repeats in Friedreich's ataxia
The DNA abnormality found in 98% of Friedreich's ataxia (FRDA) patients is the unstable
hyperexpansion of a GAA· TTC triplet repeat in the first intron of the frataxin gene. Expanded …
hyperexpansion of a GAA· TTC triplet repeat in the first intron of the frataxin gene. Expanded …
Anticancer Activities of DNA-Alkylating Pyrrole–Imidazole Polyamide Analogs Targeting RUNX Transcription Factors against p53-Mutated Pancreatic Cancer PANC-1 …
Y Hirose, S Sato, K Hashiya, T Bando… - Journal of Medicinal …, 2023 - ACS Publications
The runt-related transcription factor (RUNX) family is known to play important roles in the
progression of cancer. Conjugate 1, which covalently binds to the RUNX-binding …
progression of cancer. Conjugate 1, which covalently binds to the RUNX-binding …
Hoechst tagging: a modular strategy to design synthetic fluorescent probes for live-cell nucleus imaging
We report a general strategy to create small-molecule fluorescent probes for the nucleus in
living cells. Our strategy is based on the attachment of the DNA-binding Hoechst compound …
living cells. Our strategy is based on the attachment of the DNA-binding Hoechst compound …