Despite the great successes achieved in the fields of virology and diagnostics, several
difficulties affect improvements in hepatitis C virus (HCV) infection control and eradication in …

Since its discovery in the early 1990s, the Janus kinase (JAK)-signal transducer and
activator of transcription (STAT) signaling pathway has been found to play key roles in …

Until the mid-nineteenth century, life expectancy at birth averaged 20 years worldwide,
owing mostly to childhood fevers. The germ theory of diseases then gradually overcame the …

BACKGROUND & AIMS: Polymorphisms in IL28B were shown to affect clearance of
hepatitis C virus (HCV) infection in genome-wide association (GWA) studies. Only a fraction …

Liver carcinogenesis is a complex and multi-factorial process, in which both environmental
and genetic features interfere and contribute to malignant transformation. Patients with …

BACKGROUND & AIMS: A limited number of patients with hepatitis B e antigen (HBeAg)-
positive chronic hepatitis B respond to treatment with peginterferon alfa (PEG-IFN). We …

A sustained virological response (SVR) from HCV (synonymous with virological cure) leads
to decreased mortality, morbidity and improved quality of life, as well as a reduced incidence …

Hepatitis C virus (HCV) replication in primary liver cells is less robust than that in hepatoma
cell lines, suggesting that innate antiviral mechanisms in primary cells may limit HCV …

IFNL3, which encodes interferon-λ3 (IFN-λ3), has received considerable attention in the
hepatitis C virus (HCV) field, as many independent genome-wide association studies have …

Coronavirus disease-19 (COVID-19) describes a set of symptoms that develop following
infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whilst …