The Na+/Ca2+ exchanger, an ion transport protein, is expressed in the plasma membrane
(PM) of virtually all animal cells. It extrudes Ca2+ in parallel with the PM ATP-driven Ca2+ …

This paper is the third in a series of reviews published in this issue resulting from the
University of California Davis Cardiovascular Symposium 2014: Systems approach to …

▪ Abstract Plasma membrane Na+-Ca2+ exchange is an essential component of Ca2+
signaling pathways in several tissues. Activity is especially high in the heart where the …

Sodium/calcium (Na+/Ca2+) exchangers (NCX) are membrane transporters that play an
essential role in maintaining the homeostasis of cytosolic Ca2+ for cell signaling. We …

Mammalian Na+/Ca2+ exchangers are members of three branches of a much larger family
of transport proteins [the CaCA (Ca2+/cation antiporter) superfamily] whose main role is to …

Usher syndrome type II (USH2) is a genetically heterogeneous autosomal recessive
disorder with at least three genetic subtypes (USH2A, USH2B, and USH2C) and is classified …

Drosophila visual transduction is the fastest known G-protein-coupled signaling cascade
and has therefore served as a genetically tractable animal model for characterizing rapid …

Cation/Ca2+ exchangers are an essential component of Ca2+ signaling pathways and
function to transport cytosolic Ca2+ across membranes against its electrochemical gradient …

Abstract The Na+/Ca 2+ exchanger's family of membrane transporters is widely distributed in
cells and tissues of the animal kingdom and constitutes one of the most important …

The Na+-Ca2+ exchanger (NCX) is one of the essential regulators of Ca2+ homeostasis in
cardiomyocytes and thus an important modulator of the cardiac contractile function. The …