Immune dysregulation in sepsis: experiences, lessons and perspectives
M Cao, G Wang, J **
A Kolodyazhna, WJ Wiersinga, T van der Poll - Burns & Trauma, 2025 - academic.oup.com
According to the latest definition, sepsis is characterized by life-threatening organ
dysfunction caused by a dysregulated host response to an infection. However, this definition …
dysfunction caused by a dysregulated host response to an infection. However, this definition …
Predictive gene expression signature diagnoses neonatal sepsis before clinical presentation
Background Neonatal sepsis is a deadly disease with non-specific clinical signs, delaying
diagnosis and treatment. There remains a need for early biomarkers to facilitate timely …
diagnosis and treatment. There remains a need for early biomarkers to facilitate timely …
Validation of reference gene stability for miRNA quantification by reverse transcription quantitative PCR in the peripheral blood of patients with COVID-19 critical …
The COVID-19 pandemic has created an urgency to study the host gene response that leads
to variable clinical presentations of the disease, particularly the critical illness response …
to variable clinical presentations of the disease, particularly the critical illness response …
scCaT: An explainable capsulating architecture for sepsis diagnosis transferring from single-cell RNA sequencing
Sepsis is a life-threatening condition characterized by an exaggerated immune response to
pathogens, leading to organ damage and high mortality rates in the intensive care unit …
pathogens, leading to organ damage and high mortality rates in the intensive care unit …
Integrated Analyses of Single-Cell Transcriptome and Mendelian Randomization Reveal the Protective Role of Resistin in Sepsis Survival in Intensive Care Unit
H Chen, H Luo, T Tian, S Li, Y Jiang - International Journal of Molecular …, 2023 - mdpi.com
The high morbidity and mortality rates associated with sepsis highlight the challenges of
finding specific remedies for this condition in the intensive care unit (ICU). This study aimed …
finding specific remedies for this condition in the intensive care unit (ICU). This study aimed …
Multiomic molecular patterns of lipid dysregulation in a subphenotype of sepsis with higher shock incidence and mortality
B Augustin, D Wu, LP Black, A Bertrand, D Sulaiman… - Critical Care, 2024 - Springer
Background Lipids play a critical role in defense against sepsis. We sought to investigate
gene expression and lipidomic patterns of lipid dysregulation in sepsis. Methods Data from …
gene expression and lipidomic patterns of lipid dysregulation in sepsis. Methods Data from …
The high-density lipoprotein cholesterol (HDL-C)-concentration-dependent association between anti-inflammatory capacity and sepsis: A single-center cross-sectional …
KL Chen, RH Chou, CC Chang, CS Kuo, JH Wei… - Plos one, 2024 - journals.plos.org
Introduction Known to have pleiotropic functions, high-density lipoprotein (HDL) helps to
regulate systemic inflammation during sepsis. As preserving HDL-C level is a promising …
regulate systemic inflammation during sepsis. As preserving HDL-C level is a promising …
Factors affecting neutrophil functions during sepsis: human microbiome and epigenetics
Y Ma, Y Zhao, X Zhang - Journal of Leukocyte Biology, 2024 - academic.oup.com
Sepsis is a severe disease that occurs when the body's immune system reacts excessively
to infection. The body's response, which includes an intense anti-bacterial reaction, can …
to infection. The body's response, which includes an intense anti-bacterial reaction, can …
The Omics Complexity in Sepsis: The Limits of the Personalized Medicine Approach
Sepsis is one of the most common causes of morbidity and mortality worldwide. Despite the
remarkable advances in modern medicine throughout the last century, the mortality rates …
remarkable advances in modern medicine throughout the last century, the mortality rates …