Antipsychotic drugs: a concise review of history, classification, indications, mechanism, efficacy, side effects, dosing, and clinical application
The introduction of the first antipsychotic drug, chlorpromazine, was a milestone for
psychiatry. The authors review the history, classification, indications, mechanism, efficacy …
psychiatry. The authors review the history, classification, indications, mechanism, efficacy …
[HTML][HTML] IUPHAR review: Drug Repurposing in Schizophrenia–An Updated Review of Clinical Trials
There is an urgent need for mechanistically novel and more efficacious treatments for
schizophrenia, especially those targeting negative and cognitive symptoms with a more …
schizophrenia, especially those targeting negative and cognitive symptoms with a more …
Disability and Adverse Effects of Oral Versus Long-Acting Injectable Antipsychotics in Schizophrenia-Spectrum and Bipolar Disorder: A Comparison Based on Data …
Background Patients undergoing antipsychotic treatment for psychiatric disorders may
experience challenges in functioning, either stemming from the severity of the illness or from …
experience challenges in functioning, either stemming from the severity of the illness or from …
[HTML][HTML] Psychotropic Taxonomies: Constructing a Therapeutic Framework for Psychiatry
Pharmacological interventions are a cornerstone of psychiatric practice. The taxonomies
used to classify these interventions influence the treatment and interpretation of psychiatric …
used to classify these interventions influence the treatment and interpretation of psychiatric …
[HTML][HTML] Muscarinic receptor agonists and positive allosteric modulators in animal models of psychosis: protocol for a systematic review and meta-analysis
S Siafis, N Nomura, J Schneider-Thoma… - …, 2025 - pmc.ncbi.nlm.nih.gov
Background Muscarinic receptor agonism and positive allosteric modulation is a promising
mechanism of action for treating psychosis, not present in most D2R-blocking antipsychotics …
mechanism of action for treating psychosis, not present in most D2R-blocking antipsychotics …
How antipsychotics work in schizophrenia: a primer on mechanisms
JM Meyer - CNS spectrums, 2024 - cambridge.org
Antipsychotics effective for schizophrenia approved prior to 2024 shared the common
mechanism of postsynaptic dopamine D2 receptor antagonism or partial agonism. Positive …
mechanism of postsynaptic dopamine D2 receptor antagonism or partial agonism. Positive …