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From immunology to artificial intelligence: revolutionizing latent tuberculosis infection diagnosis with machine learning
LS Li, L Yang, L Zhuang, ZY Ye, WG Zhao… - Military Medical …, 2023 - Springer
Latent tuberculosis infection (LTBI) has become a major source of active tuberculosis (ATB).
Although the tuberculin skin test and interferon-gamma release assay can be used to …
Although the tuberculin skin test and interferon-gamma release assay can be used to …
Mycobacterium tuberculosis: success through dormancy
Tuberculosis (TB) remains a major health threat, killing nearly 2 million individuals around
this globe, annually. The only vaccine, developed almost a century ago, provides limited …
this globe, annually. The only vaccine, developed almost a century ago, provides limited …
Genomics of Actinobacteria: Tracing the Evolutionary History of an Ancient Phylum
Actinobacteria constitute one of the largest phyla among Bacteria and represent gram-
positive bacteria with a high G+ C content in their DNA. This bacterial group includes …
positive bacteria with a high G+ C content in their DNA. This bacterial group includes …
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies
Professional phagocytes have a vast and sophisticated arsenal of microbicidal features.
They are capable of ingesting and destroying invading organisms, and can present …
They are capable of ingesting and destroying invading organisms, and can present …
Genomic islands: tools of bacterial horizontal gene transfer and evolution
Bacterial genomes evolve through mutations, rearrangements or horizontal gene transfer.
Besides the core genes encoding essential metabolic functions, bacterial genomes also …
Besides the core genes encoding essential metabolic functions, bacterial genomes also …
ESX‐1 and phthiocerol dimycocerosates of Mycobacterium tuberculosis act in concert to cause phagosomal rupture and host cell apoptosis
Although phthiocerol dimycocerosates (DIM) are major virulence factors of Mycobacterium
tuberculosis (Mtb), the causative agent of human tuberculosis, little is known about their …
tuberculosis (Mtb), the causative agent of human tuberculosis, little is known about their …
Terpene biosynthesis: modularity rules
Terpenes are the largest class of small‐molecule natural products on earth, and the most
abundant by mass. Here, we summarize recent developments in elucidating the structure …
abundant by mass. Here, we summarize recent developments in elucidating the structure …
A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages
Induction of lipid-laden foamy macrophages is a cellular hallmark of tuberculosis (TB)
disease, which involves the transformation of infected phagolysosomes from a site of killing …
disease, which involves the transformation of infected phagolysosomes from a site of killing …
[HTML][HTML] Mycobacterium tuberculosis suppresses host DNA repair to boost its intracellular survival
S Liu, L Guan, C Peng, Y Cheng, H Cheng, F Wang… - Cell Host & Microbe, 2023 - cell.com
Mycobacterium tuberculosis (Mtb) triggers distinct changes in macrophages, resulting in the
formation of lipid droplets that serve as a nutrient source. We discover that Mtb promotes …
formation of lipid droplets that serve as a nutrient source. We discover that Mtb promotes …
Who puts the tubercle in tuberculosis?
Tuberculosis (TB), an illness that mainly affects the respiratory system, is one of the world's
most pernicious diseases. TB currently infects one-third of the world's population and kills …
most pernicious diseases. TB currently infects one-third of the world's population and kills …