AIMS: Tuberculosis and mental illness share common risk factors including homelessness,
HIV positive serology, alcohol/substance abuse and migrant status leading to frequent …

Advances in psychiatric neuroscience have transformed our understanding of impaired and
spared brain functions in psychotic illnesses. Despite substantial progress, few (if any) …

NMDA-type glutamate receptors are ligand-gated ion channels that mediate a major
component of excitatory neurotransmission in the central nervous system (CNS). They are …

Background Investigators are urgently searching for options to treat negative symptoms in
schizophrenia because these symptoms are disabling and do not respond adequately to …

The development of new techniques to study glial cells has revealed that they are active
participants in the development of functional neuronal circuits. Calcium imaging studies …

D-Cycloserine, known from tuberculosis therapy, has been widely introduced to
neuropsychiatric studies, since its central active mechanism as a partial NMDA-agonist has …

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ABSTRACT Preclinical Research After the identification of the schizophrenia as an illness
over a century ago, treatment of affected individuals included unspecific, mostly very robust …

Schizophrenia is associated with deficits in cortical plasticity that affect sensory brain regions
and lead to impaired cognitive performance. Here we examined underlying neural …

Although psychiatry has a rich variety of models, most fail to span biological, psychological,
and social domains. Computational psychiatry offers simple, direct ways of uniting these …