Central chemoreception traditionally refers to a change in ventilation attributable to changes
in CO2/H+ detected within the brain. Interest in central chemoreception has grown …

By definition central respiratory chemoreceptors (CRCs) are cells that are sensitive to
changes in brain PCO2 or pH and contribute to the stimulation of breathing elicited by …

The rat retrotrapezoid nucleus (RTN) contains pH‐sensitive neurons that are putative central
chemoreceptors. Here, we examined whether these neurons respond to peripheral …

Serotonergic neurons project widely throughout the CNS and modulate many different brain
functions. Particularly important, but controversial, are the contributions of serotonin (5-HT) …

CENTRAL CHEMORECEPTION refers to detection of CO2/pH within the brain and the
subsequent reflex effects on breathing. It involves multiple sites within the hindbrain (9, 12 …

We used optogenetics to determine the global respiratory effects produced by selectively
stimulating raphe obscurus (RO) serotonergic neurons in anesthetized mice and to test …

The 'distributed chemoreception theory'attributes the central chemoreflex (the stimulation of
breathing by CNS acidification) to the cumulative effects of pH on multiple classes of …

Adenosine is an inhibitory modulator of neuronal excitability. Neuronal activity results in
increased adenosine release, thereby constraining excessive excitation. The exceptionally …

Serotonergic (5-HT) neurons are putative central respiratory chemoreceptors, aiding in the
brain's ability to detect arterial changes in [Formula: see text] and implement appropriate …

The rat retrotrapezoid nucleus (RTN) contains neurons described as central chemoreceptors
in the adult and respiratory rhythm-generating pacemakers in neonates [parafacial …