MicroRNA

TX Lu, ME Rothenberg - Journal of allergy and clinical immunology, 2018 - Elsevier
MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene-expression
posttranscriptionally. MiRNA research in allergy is expanding because miRNAs are crucial …

Endogenous microRNA sponges: evidence and controversy

DW Thomson, ME Dinger - Nature Reviews Genetics, 2016 - nature.com
The competitive endogenous RNA (ceRNA) hypothesis proposes that transcripts with
shared microRNA (miRNA) binding sites compete for post-transcriptional control. This …

[HTML][HTML] Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis

SA Melo, H Sugimoto, JT O'Connell, N Kato… - Cancer cell, 2014 - cell.com
Exosomes are secreted by all cell types and contain proteins and nucleic acids. Here, we
report that breast cancer associated exosomes contain microRNAs (miRNAs) associated …

Transfection types, methods and strategies: a technical review

ZX Chong, SK Yeap, WY Ho - PeerJ, 2021 - peerj.com
Transfection is a modern and powerful method used to insert foreign nucleic acids into
eukaryotic cells. The ability to modify host cells' genetic content enables the broad …

MicroRNA delivery through nanoparticles

SWL Lee, C Paoletti, M Campisi, T Osaki… - Journal of Controlled …, 2019 - Elsevier
MicroRNAs (miRNAs) are attracting a growing interest in the scientific community due to
their central role in the etiology of major diseases. On the other hand, nanoparticle carriers …

The regulatory role of microRNAs in breast cancer

HY Loh, BP Norman, KS Lai, NMANA Rahman… - International journal of …, 2019 - mdpi.com
MicroRNAs (miRNAs) are small non-coding RNA molecules which function as critical post-
transcriptional gene regulators of various biological functions. Generally, miRNAs negatively …

Recent advances in microscale electroporation

SE Choi, H Khoo, SC Hur - Chemical reviews, 2022 - ACS Publications
Electroporation (EP) is a commonly used strategy to increase cell permeability for
intracellular cargo delivery or irreversible cell membrane disruption using electric fields. In …

Nucleic acid drugs: recent progress and future perspectives

X Sun, S Setrerrahmane, C Li, J Hu, H Xu - Signal Transduction and …, 2024 - nature.com
High efficacy, selectivity and cellular targeting of therapeutic agents has been an active area
of investigation for decades. Currently, most clinically approved therapeutics are small …

Transfection of microRNA mimics should be used with caution

HY **, A Gonzalez-Martin, AV Miletic, M Lai… - Frontiers in …, 2015 - frontiersin.org
Transient transfection of chemically synthesized microRNA (miRNA) mimics is being used
extensively to study the functions and mechanisms of endogenous miRNAs. However, it …

Pancreatic cancer‐secreted miR‐155 implicates in the conversion from normal fibroblasts to cancer‐associated fibroblasts

W Pang, J Su, Y Wang, H Feng, X Dai, Y Yuan… - Cancer …, 2015 - Wiley Online Library
Cancer‐associated fibroblasts (CAF) are a major constituent of the pancreatic cancer
microenvironment and that the meaning is as intended. Pancreatic cancer cells can induce …