α, β-Unsaturated chalcone moieties and quinoline scaffolds play an important role in
medicinal chemistry, especially in the identification and development of potential anticancer …

Although a number of anti-inflammatory drugs have been discovered and developed to treat
diseases associated with acute and chronic inflammation, many anti-inflammatories cause …

Quinoline-based small molecules have been explored and being developed as anti-
inflammatory agents targeting several pharmacological targets namely Phosphodiesterase 4 …

Nimesulide is a nonsteroidal anti-inflammatory drug possessing analgesic and antipyretic
properties. This drug is considered a selective cyclooxygenase-2 (COX-2) inhibitor and …

Abstract Phosphodiesterase 4B (PDE4B) is a member of the phosphodiesterase family of
proteins that plays a critical role in regulating intracellular levels of cyclic adenosine …

Abstract A new class of 1, 2, 3-triazol derivatives derived from nimesulide was designed as
potential inhibitors of PDE4B. Synthesis of these compounds was carried out via a multi-step …

A novel series of unsymmetrical bis-quinolin-3-yl chalcones has been synthesized under
visible light using a Claisen–Schmidt condensation reaction between the 2-(morpholine …

A new hybrid template designed by linking three pharmacophoric groups, for example,
quinoline, triazole and dihydroquinoline moieties have been used for the generation of a …

Construction of a six-membered fused N -heterocyclic ring via a new 3-component reaction:
synthesis of (pyrazolo)pyrimidines/pyridines - Chemical Communications (RSC Publishing) …

Montmorillonite K-10 mediated green and one-pot synthesis of 2-substituted quinolines has
been accomplished via a 3-component reaction of aniline, aldehydes and ethyl 3, 3 …