Mass spectrometry (MS) has become one of the key technologies of structural biology. In this
review, the contributions of chemical cross-linking combined with mass spectrometry (XL …

Cross-linking mass spectrometry (XL-MS) has matured into a potent tool to identify protein–
protein interactions or to uncover protein structures in living cells, tissues, or organelles. The …

We describe pLink 2, a search engine with higher speed and reliability for proteome-scale
identification of cross-linked peptides. With a two-stage open search strategy facilitated by …

The majority of processes that occur in daily cell life are modulated by hundreds to
thousands of dynamic protein–protein interactions (PPI). The resulting protein complexes …

The exploration of protein structure and function stands at the forefront of life science and
represents an ever‐expanding focus in the development of proteomics. As mass …

Crosslinking mass spectrometry (XL-MS) is a valuable technique for generating point-to-
point distance measurements in protein space. However, cell-based XL-MS experiments …

Various protein cross‐linking reactions leading to molecular polymerization and covalent
aggregates have been described in processed foods. They are an undesired side effect of …

Improving the sensitivity of protein–protein interaction detection and protein structure
probing is a principal challenge in cross-linking mass spectrometry (XL-MS) data analysis. In …

The field of crosslinking mass spectrometry has seen substantial advancements over the
past decades, enabling the structural analysis of proteins and protein complexes and …

Background Cross-linking mass spectrometry (XL-MS) is a powerful technique for detecting
protein–protein interactions (PPIs) and modeling protein structures in a high-throughput …