Mitochondria are best known for harboring pathways involved in ATP synthesis through the
tricarboxylic acid cycle and oxidative phosphorylation. Major advances in understanding …

Environmental metabolomics is the application of metabolomics to characterise the
interactions of organisms with their environment. This approach has many advantages for …

Mitochondrial dysfunction is associated with a spectrum of human disorders, ranging from
rare, inborn errors of metabolism to common, age-associated diseases such as …

Mitochondria are dynamic bioenergetic organelles whose maintenance requires around
1500 proteins from two genomes. Mutations in either the mitochondrial or nuclear genome …

Cells respond to defects in mitochondrial function by activating signaling pathways that
restore homeostasis. The mitochondrial peptide exporter HAF-1 and the bZip transcription …

The field of metabolomics continues to grow rapidly over the last decade and has been
proven to be a powerful technology in predicting and explaining complex phenotypes in …

Mitochondria are small cellular constituents that generate cellular energy (ATP) by oxidative
phosphorylation (OXPHOS). Dysfunction of these organelles is linked to a heterogeneous …

Metabolism is controlled to ensure organismal development and homeostasis. Several
mechanisms regulate metabolism, including allosteric control and transcriptional regulation …

Mitochondrial disease (MD) diagnostics and disease progression investigations have
traditionally relied very little on metabolic data, due to a lack of biomarker sensitivity and …

Every 5 years or so new technologies, or new combinations of old ones, seemingly burst
onto the science scene and are then sought after until they reach the point of becoming …