Regulation of axonal regeneration after mammalian spinal cord injury

B Zheng, MH Tuszynski - Nature Reviews Molecular Cell Biology, 2023 - nature.com
One hundred years ago, Ramón y Cajal, considered by many as the founder of modern
neuroscience, stated that neurons of the adult central nervous system (CNS) are incapable …

Traumatic spinal cord injury: an overview of pathophysiology, models and acute injury mechanisms

A Alizadeh, SM Dyck, S Karimi-Abdolrezaee - Frontiers in neurology, 2019 - frontiersin.org
Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …

Moving beyond the glial scar for spinal cord repair

EJ Bradbury, ER Burnside - Nature communications, 2019 - nature.com
Traumatic spinal cord injury results in severe and irreversible loss of function. The injury
triggers a complex cascade of inflammatory and pathological processes, culminating in …

Current advancements in spinal cord Injury Research—glial scar formation and neural regeneration

T Clifford, Z Finkel, B Rodriguez, A Joseph, L Cai - Cells, 2023 - mdpi.com
Spinal cord injury (SCI) is a complex tissue injury resulting in permanent and degenerating
damage to the central nervous system (CNS). Detrimental cellular processes occur after SCI …

Integrating hydrogels manipulate ECM deposition after spinal cord injury for specific neural reconnections via neuronal relays

Z Tan, L **ao, J Ma, K Shi, J Liu, F Feng, P **e… - Science …, 2024 - science.org
A bioinspired hydrogel composed of hyaluronic acid-graft-dopamine (HADA) and a designer
peptide HGF-(RADA) 4-DGDRGDS (HRR) was presented to enhance tissue integration …

Natural and targeted circuit reorganization after spinal cord injury

MA Anderson, JW Squair, M Gautier, TH Hutson… - Nature …, 2022 - nature.com
A spinal cord injury disrupts communication between the brain and the circuits in the spinal
cord that regulate neurological functions. The consequences are permanent paralysis, loss …

Emerging roles for CNS fibroblasts in health, injury and disease

CE Dorrier, HE Jones, L Pintarić… - Nature Reviews …, 2022 - nature.com
Recent transcriptomic, histological and functional studies have begun to shine light on the
fibroblasts present in the meninges, choroid plexus and perivascular spaces of the brain and …

Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull–meninges connections

R Cai, C Pan, A Ghasemigharagoz, MI Todorov… - Nature …, 2019 - nature.com
Abstract Analysis of entire transparent rodent bodies after clearing could provide holistic
biological information in health and disease, but reliable imaging and quantification of …

Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury

V Bellver-Landete, F Bretheau, B Mailhot… - Nature …, 2019 - nature.com
The role of microglia in spinal cord injury (SCI) remains poorly understood and is often
confused with the response of macrophages. Here, we use specific transgenic mouse lines …

The translational landscape in spinal cord injury: focus on neuroplasticity and regeneration

TH Hutson, S Di Giovanni - Nature Reviews Neurology, 2019 - nature.com
Over the past decade, we have witnessed a flourishing of novel strategies to enhance
neuroplasticity and promote axon regeneration following spinal cord injury, and results from …