Injuries to articular cartilage and menisci can lead to cartilage degeneration that ultimately
results in arthritis. Different forms of arthritis affect~ 50 million people in the USA alone, and it …

Epigenetic regulation of mitochondrial DNA (mtDNA) is an emerging and fast-develo**
field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic …

Cellular reprogramming can manipulate the identity of cells to generate the desired cell
types,–. The use of cell intrinsic components, including oocyte cytoplasm and transcription …

We recently demonstrated the chemical reprogramming of human somatic cells to
pluripotent stem cells (hCiPSCs), which provides a robust approach for cell fate …

Among all tumor suppressor microRNAs, reduced let-7 expression occurs most frequently in
cancer and typically correlates with poor prognosis. Activation of either LIN28A or LIN28B …

Pioneer transcription factors (TFs) access silent chromatin and initiate cell-fate changes,
using diverse types of DNA binding domains (DBDs). FoxA, the paradigm pioneer TF, has a …

Hepatocellular carcinoma (HCC) is an increasing burden on global public health and is
associated with enhanced lipogenesis, fatty acid uptake, and lipid metabolic …

A distinctive feature of stem cells is their capacity to self-renew to maintain pluripotency.
Studies of genetically-engineered mouse models and recent advances in metabolomic …

Metabolomics answers a fundamental question in biology: How does metabolism respond to
genetic, environmental or phenotypic perturbations? Combining several metabolomics …

In this study, we present integrated quantitative proteome, transcriptome, and methylome
analyses of hematopoietic stem cells (HSCs) and four multipotent progenitor (MPP) …