The secretion profile of mesenchymal stem cells and potential applications in treating human diseases

Y Han, J Yang, J Fang, Y Zhou, E Candi… - Signal transduction and …, 2022 - nature.com
Mesenchymal stromal/stem cells (MSCs) possess multi-lineage differentiation and self-
renewal potentials. MSCs-based therapies have been widely utilized for the treatment of …

Microglia-mediated neuroinflammation and neuroplasticity after stroke

Y Wang, RK Leak, G Cao - Frontiers in cellular neuroscience, 2022 - frontiersin.org
Stroke remains a major cause of long-term disability and mortality worldwide. The immune
system plays an important role in determining the condition of the brain following stroke. As …

Photoreceptor protection by mesenchymal stem cell transplantation identifies exosomal MiR-21 as a therapeutic for retinal degeneration

CL Deng, CB Hu, ST Ling, N Zhao, LH Bao… - Cell Death & …, 2021 - nature.com
Photoreceptor apoptosis is recognized as one key pathogenesis of retinal degeneration, the
counteraction of which represents a promising approach to safeguard visual function …

[HTML][HTML] Stem-cell-based therapy: the celestial weapon against neurological disorders

MA Zayed, S Sultan, HO Alsaab, SM Yousof, GI Alrefaei… - Cells, 2022 - mdpi.com
Stem cells are a versatile source for cell therapy. Their use is particularly significant for the
treatment of neurological disorders for which no definitive conventional medical treatment is …

Inflammatory cytokines as mediators of retinal endothelial barrier dysfunction in non‐infectious uveitis

LB Ferreira, KA Williams, G Best… - Clinical & …, 2023 - Wiley Online Library
Characterised by intraocular inflammation, non‐infectious uveitis includes a large group of
autoimmune and autoinflammatory diseases that either involve the eye alone or have both …

[HTML][HTML] Mesenchymal stromal cell secretome for traumatic brain injury: Focus on immunomodulatory action

F Pischiutta, E Caruso, H Cavaleiro, AJ Salgado… - Experimental …, 2022 - Elsevier
The severity and long-term consequences of brain damage in traumatic brain injured (TBI)
patients urgently calls for better neuroprotective/neuroreparative strategies for this …

Mesenchymal stromal cell derived extracellular vesicles as a therapeutic tool: immune regulation, MSC priming, and applications to SLE

C Wong, I Stoilova, F Gazeau, JP Herbeuval… - Frontiers in …, 2024 - frontiersin.org
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by a
dysfunction of the immune system. Mesenchymal stromal cell (MSCs) derived extracellular …

[HTML][HTML] Secretome as a Tool to Treat Neurological Conditions: Are We Ready?

AV da Silva, I Serrenho, B Araújo, AM Carvalho… - International Journal of …, 2023 - mdpi.com
Due to their characteristics, mesenchymal stem cells (MSCs) are considered a potential
therapy for brain tissue injury or degeneration. Nevertheless, despite the promising results …

The implications of microglial regulation in neuroplasticity-dependent stroke recovery

C Qiao, Z Liu, S Qie - Biomolecules, 2023 - mdpi.com
Stroke causes varying degrees of neurological deficits, leading to corresponding
dysfunctions. There are different therapeutic principles for each stage of pathological …

Aryl hydrocarbon receptor dependent anti-inflammation and neuroprotective effects of tryptophan metabolites on retinal ischemia/reperfusion injury

Y Yang, N Wang, L Xu, Y Liu, L Huang, M Gu… - Cell death & …, 2023 - nature.com
Glaucoma is the major cause of irreversible blindness in the world characterized by
progressive retinal neurodegeneration, in which local inflammation in retina is involved in …