Neuroinflammatory markers: key indicators in the pathology of neurodegenerative diseases
Neuroinflammation, a protective response of the central nervous system (CNS), is
associated with the pathogenesis of neurodegenerative diseases. The CNS is composed of …
associated with the pathogenesis of neurodegenerative diseases. The CNS is composed of …
[HTML][HTML] Astrogliosis as a therapeutic target for neurodegenerative diseases
Chronic neurodegenerative diseases represent major unmet needs for therapeutic
interventions. Recently, the neurocentric view of brain function and disease has been …
interventions. Recently, the neurocentric view of brain function and disease has been …
Neuroinflammation, microglia, and cell-association during prion disease
JA Carroll, B Chesebro - Viruses, 2019 - mdpi.com
Prion disorders are transmissible diseases caused by a proteinaceous infectious agent that
can infect the lymphatic and nervous systems. The clinical features of prion diseases can …
can infect the lymphatic and nervous systems. The clinical features of prion diseases can …
On the central role of brain connectivity in neurodegenerative disease progression
Increased brain connectivity, in all its variants, is often considered an evolutionary
advantage by mediating complex sensorimotor function and higher cognitive faculties …
advantage by mediating complex sensorimotor function and higher cognitive faculties …
Neuropathology of animal prion diseases
Transmissible Spongiform Encephalopathies (TSEs) or prion diseases are a fatal group of
infectious, inherited and spontaneous neurodegenerative diseases affecting human and …
infectious, inherited and spontaneous neurodegenerative diseases affecting human and …
Prion infection of mouse brain reveals multiple new upregulated genes involved in neuroinflammation or signal transduction
JA Carroll, JF Striebel, B Race, K Phillips… - Journal of …, 2015 - Am Soc Microbiol
Gliosis is often a preclinical pathological finding in neurodegenerative diseases, including
prion diseases, but the mechanisms facilitating gliosis and neuronal damage in these …
prion diseases, but the mechanisms facilitating gliosis and neuronal damage in these …
Coordinated gene expression of neuroinflammatory and cell signaling markers in dorsolateral prefrontal cortex during human brain development and aging
Background Age changes in expression of inflammatory, synaptic, and neurotrophic genes
are not well characterized during human brain development and senescence. Knowing …
are not well characterized during human brain development and senescence. Knowing …
Oxidative and inflammatory events in prion diseases: can they be therapeutic targets?
KN Prasad, SC Bondy - Current aging science, 2018 - ingentaconnect.com
Prion diseases are a group of incurable infectious terminal neurodegenerative diseases
caused by the aggregated misfolded PrPsc in selected mammals including humans. The …
caused by the aggregated misfolded PrPsc in selected mammals including humans. The …
Discrimination of prion strain targeting in the central nervous system via reactive astrocyte heterogeneity in CD44 expression
Prion diseases or transmissible spongiform encephalopathies are fatal, progressive,
neurodegenerative, protein-misfolding disorders. Prion diseases may arise spontaneously …
neurodegenerative, protein-misfolding disorders. Prion diseases may arise spontaneously …
Single_cell_GRN: gene regulatory network identification based on supervised learning method and Single-cell RNA-seq data
B Yang, W Bao, B Chen, D Song - BioData Mining, 2022 - Springer
Single-cell RNA-seq overcomes the shortcomings of conventional transcriptome sequencing
technology and could provide a powerful tool for distinguishing the transcriptome …
technology and could provide a powerful tool for distinguishing the transcriptome …