GFR is the best indicator of renal function in children and adolescents and is critical for
diagnosing acute and chronic kidney impairment, intervening early to prevent end-stage …

Glomerular filtration rate (GFR) assesses kidney function. GFR is measured by renal
clearance techniques; inulin clearance is the gold standard but is not easily measured …

The Schwartz formula was devised in the mid-1970s to estimate GFR in children. Recent
data suggest that this formula currently overestimates GFR as measured by plasma …

The Chronic Kidney Disease in Children study is a cohort of about 600 children with chronic
kidney disease (CKD) in the United States and Canada. The independent variable for our …

Critically ill patients are at highest risk for acute kidney injury (AKI), or abrupt renal
dysfunction. Before 2004, most pediatric AKI literature reported on the technical feasibility …

Background Renal inulin clearance is the gold standard for evaluation of kidney function, but
cannot be measured easily in children. Therefore, we utilize the serum creatinine (Cr)-based …

Plasma or serum creatinine is the most commonly used diagnostic marker for the estimation
of glomerular filtration rate (GFR) in clinical routine. Due to substantial pre-analytical and …

Renal function is essential for homeostasis. The kidneys play important pleiotropic roles
including removal of metabolic waste products and maintenance of water–electrolyte …

Neonates who are critically ill are at high risk for acute kidney injury (AKI) as the result of
several potential exposures (eg, nephrotoxic medications, sepsis, hypotension, adverse …

Cystatin C is a low-molecular-weight protein which has been proposed as a marker of renal
function that could replace creatinine. Indeed, the concentration of cystatin C is mainly …